CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION
Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection. Objective. To study the indices of CD3+CD4+CD8+ dou...
| Main Authors: | , |
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| Format: | Article |
| Language: | Belarusian |
| Published: |
Grodno State Medical University
2020-03-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2495 |
| _version_ | 1828944933650694144 |
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| author | Zybleva S. V. Zyblev S. L. |
| author_facet | Zybleva S. V. Zyblev S. L. |
| author_sort | Zybleva S. V. |
| collection | DOAJ |
| description | Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection.
Objective. To study the indices of CD3+CD4+CD8+ double- positive T-lymphocytes before kidney transplantation in patients with early allograft dysfunction.
Material and Methods. We examined 199 recipients who underwent kidney transplantation. CD3+CD4+CD8+
count was determined before transplantation. All the patients were divided into 2 groups: those with primary graft function (PGF) and those with graft dysfunction (PGD). A correlation analysis was performed between the values of CD3+CD4+CD8+ and the biomarkers indices of allograft function on the 7th day.
Results. Before transplantation the CD3+CD4+CD8+ count was significantly lower in recipients with early allograft dysfunction as compared to the group with primary allograft function. The CD3+CD4+CD8+ indices were determined to predict the development of early allograft dysfunction.
Conclusions. The CD3+CD4+CD8+ indices in recipients before kidney transplantation can be used to predict the
development of early allograft dysfunction. |
| first_indexed | 2024-12-14T04:42:56Z |
| format | Article |
| id | doaj.art-38adee3124af435fb486a722ec6dbdcc |
| institution | Directory Open Access Journal |
| issn | 2221-8785 2413-0109 |
| language | Belarusian |
| last_indexed | 2024-12-14T04:42:56Z |
| publishDate | 2020-03-01 |
| publisher | Grodno State Medical University |
| record_format | Article |
| series | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| spelling | doaj.art-38adee3124af435fb486a722ec6dbdcc2022-12-21T23:16:45ZbelGrodno State Medical UniversityŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092020-03-01181172010.25298/2221-8785-2020-18-1-17-20CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTIONZybleva S. V.0https://orcid.org/0000-0003-3061-5324Zyblev S. L.1https://orcid.org/0000-0002-0968-6630Republican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusRepublican Research Center for Radiation Medicine and Human Ecology, Gomel, BelarusBackground. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection. Objective. To study the indices of CD3+CD4+CD8+ double- positive T-lymphocytes before kidney transplantation in patients with early allograft dysfunction. Material and Methods. We examined 199 recipients who underwent kidney transplantation. CD3+CD4+CD8+ count was determined before transplantation. All the patients were divided into 2 groups: those with primary graft function (PGF) and those with graft dysfunction (PGD). A correlation analysis was performed between the values of CD3+CD4+CD8+ and the biomarkers indices of allograft function on the 7th day. Results. Before transplantation the CD3+CD4+CD8+ count was significantly lower in recipients with early allograft dysfunction as compared to the group with primary allograft function. The CD3+CD4+CD8+ indices were determined to predict the development of early allograft dysfunction. Conclusions. The CD3+CD4+CD8+ indices in recipients before kidney transplantation can be used to predict the development of early allograft dysfunction.http://journal-grsmu.by/index.php/ojs/article/view/2495cd3+cd4+cd8+ t-lymphocytes |
| spellingShingle | Zybleva S. V. Zyblev S. L. CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta cd3+cd4+cd8+ t-lymphocytes |
| title | CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION |
| title_full | CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION |
| title_fullStr | CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION |
| title_full_unstemmed | CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION |
| title_short | CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION |
| title_sort | cd3 cd4 cd8 t lymphocytes count in prognosis of early kidney allograft dysfunction |
| topic | cd3+cd4+cd8+ t-lymphocytes |
| url | http://journal-grsmu.by/index.php/ojs/article/view/2495 |
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