A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World
Electrowetting on dielectric-based digital microfluidic platforms (EWOD-DMF) have a potential to impact point-of-care diagnostics. Conventionally, EWOD-DMF platforms are manufactured in cleanrooms by expert technicians using costly and time consuming micro-nanofabrication processes such as optical l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/20/12/3593 |
| _version_ | 1827714250763665408 |
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| author | Kushal Joshi Vanessa Velasco Rahim Esfandyarpour |
| author_facet | Kushal Joshi Vanessa Velasco Rahim Esfandyarpour |
| author_sort | Kushal Joshi |
| collection | DOAJ |
| description | Electrowetting on dielectric-based digital microfluidic platforms (EWOD-DMF) have a potential to impact point-of-care diagnostics. Conventionally, EWOD-DMF platforms are manufactured in cleanrooms by expert technicians using costly and time consuming micro-nanofabrication processes such as optical lithography, depositions and etching. However, such high-end microfabrication facilities are extremely challenging to establish in resource-poor and low-income countries, due to their high capital investment and operating costs. This makes the fabrication of EWOD-DMF platforms extremely challenging in low-income countries, where such platforms are most needed for many applications such as point-of-care testing applications. To address this challenge, we present a low-cost and simple fabrication procedure for EWOD-DMF electrode arrays, which can be performed anywhere with a commercial office inkjet printer without the need of expensive cleanroom facilities. We demonstrate the utility of our platform to move and mix droplets of different reagents and physiologically conductive buffers, thereby showing its capability to potentially perform a variety of biochemical assays. By combining our low-cost, inkjet-printed EWOD-DMF platform with smartphone imaging technology and a compact control system for droplet manipulation, we also demonstrate a portable and hand-held device which can be programmed to potentially perform a variety of biochemical assays. |
| first_indexed | 2024-03-10T18:53:07Z |
| format | Article |
| id | doaj.art-38ae1939b5fa4d84bff6faaf998f0b9a |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T18:53:07Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-38ae1939b5fa4d84bff6faaf998f0b9a2023-11-20T04:57:40ZengMDPI AGSensors1424-82202020-06-012012359310.3390/s20123593A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing WorldKushal Joshi0Vanessa Velasco1Rahim Esfandyarpour2Department of Biomedical Engineering, University of California, Irvine, CA 92697, USABiochemistry Department, Stanford University, Palo Alto, CA 92697, USADepartment of Biomedical Engineering, University of California, Irvine, CA 92697, USAElectrowetting on dielectric-based digital microfluidic platforms (EWOD-DMF) have a potential to impact point-of-care diagnostics. Conventionally, EWOD-DMF platforms are manufactured in cleanrooms by expert technicians using costly and time consuming micro-nanofabrication processes such as optical lithography, depositions and etching. However, such high-end microfabrication facilities are extremely challenging to establish in resource-poor and low-income countries, due to their high capital investment and operating costs. This makes the fabrication of EWOD-DMF platforms extremely challenging in low-income countries, where such platforms are most needed for many applications such as point-of-care testing applications. To address this challenge, we present a low-cost and simple fabrication procedure for EWOD-DMF electrode arrays, which can be performed anywhere with a commercial office inkjet printer without the need of expensive cleanroom facilities. We demonstrate the utility of our platform to move and mix droplets of different reagents and physiologically conductive buffers, thereby showing its capability to potentially perform a variety of biochemical assays. By combining our low-cost, inkjet-printed EWOD-DMF platform with smartphone imaging technology and a compact control system for droplet manipulation, we also demonstrate a portable and hand-held device which can be programmed to potentially perform a variety of biochemical assays.https://www.mdpi.com/1424-8220/20/12/3593biochipelectrowetting on dielectric (EWOD)digital microfluidics (DMF)point-of-care (POC) diagnosticsdeveloping worldportable |
| spellingShingle | Kushal Joshi Vanessa Velasco Rahim Esfandyarpour A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World Sensors biochip electrowetting on dielectric (EWOD) digital microfluidics (DMF) point-of-care (POC) diagnostics developing world portable |
| title | A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World |
| title_full | A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World |
| title_fullStr | A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World |
| title_full_unstemmed | A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World |
| title_short | A Low-Cost, Disposable and Portable Inkjet-Printed Biochip for the Developing World |
| title_sort | low cost disposable and portable inkjet printed biochip for the developing world |
| topic | biochip electrowetting on dielectric (EWOD) digital microfluidics (DMF) point-of-care (POC) diagnostics developing world portable |
| url | https://www.mdpi.com/1424-8220/20/12/3593 |
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