Preliminary validation system for cuffless blood pressure measurement
The development of a non-invasive, cuffless, continuous, wearable device for the measurement of blood pressure is a complex endeavour due to the high specificity at each measuring site and the need for high accuracy. Proof-ofconcept and validation of a prototype should be performed at an early stage...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2022-1049 |
| _version_ | 1797947877480202240 |
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| author | Gonçalves Seabra Ana Carolina Ferreira da Silva Alexandre Stieglitz Thomas Belen Amado-Rey Ana |
| author_facet | Gonçalves Seabra Ana Carolina Ferreira da Silva Alexandre Stieglitz Thomas Belen Amado-Rey Ana |
| author_sort | Gonçalves Seabra Ana Carolina |
| collection | DOAJ |
| description | The development of a non-invasive, cuffless, continuous, wearable device for the measurement of blood pressure is a complex endeavour due to the high specificity at each measuring site and the need for high accuracy. Proof-ofconcept and validation of a prototype should be performed at an early stage for functionality assessment. Additionally, the emergence of biological computer models allows for in-silico research, which results should be verified in a practical experiment. To grant an optimal preliminary assessment of a prototype, this work aimed to develop and validate accurate in-vitro and ex-vivo arterial models, with simple construction and easily available components. The comparison between a silicone tube and a porcine artery as a mimicked human radial artery was based on the stiffness parameter. Flow pressure is controlled by a centrifugal heart-like pump. Pressure values are extracted with ultrasound and a commercial piezoresistive pressure sensor is used for pressure validation. The porcine artery showed much more realistic stiffness values (·=15.360) than the silicon tube (·=543.420), which was very stiff in comparison to the typical in-vivo radial artery stiffness (·=9.5). The decrease in stiffness of 97.173 % (from the silicone tube to the porcine artery) led to an acute decrease in the derived pressure error. This work serves as guidelines for the development of a low-budget arm phantom, as the simple setup allowed for a primary validation of a proof-of-concept ultrasound-based sensor for the measurement of pressure. |
| first_indexed | 2024-04-10T21:33:33Z |
| format | Article |
| id | doaj.art-38ae7b08425c4e1cb17b1cfcf8bc5d52 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-10T21:33:33Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-38ae7b08425c4e1cb17b1cfcf8bc5d522023-01-19T12:47:02ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042022-09-018218919210.1515/cdbme-2022-1049Preliminary validation system for cuffless blood pressure measurementGonçalves Seabra Ana Carolina0Ferreira da Silva Alexandre1Stieglitz Thomas2Belen Amado-Rey Ana3Laboratory for Biomedical Microtechnology (IMTEK), Albert- Ludwig-UniversityFreiburg, GermanyCenter of MicroElectroMechanical Systems (CMEMS), University of Minho,Minho, PortugalLaboratory for Biomedical Microtechnology (IMTEK), Albert-Ludwig-University,Freiburg, GermanyLaboratory for Biomedical Microtechnology (IMTEK), Albert-Ludwig-University,Freiburg, GermanyThe development of a non-invasive, cuffless, continuous, wearable device for the measurement of blood pressure is a complex endeavour due to the high specificity at each measuring site and the need for high accuracy. Proof-ofconcept and validation of a prototype should be performed at an early stage for functionality assessment. Additionally, the emergence of biological computer models allows for in-silico research, which results should be verified in a practical experiment. To grant an optimal preliminary assessment of a prototype, this work aimed to develop and validate accurate in-vitro and ex-vivo arterial models, with simple construction and easily available components. The comparison between a silicone tube and a porcine artery as a mimicked human radial artery was based on the stiffness parameter. Flow pressure is controlled by a centrifugal heart-like pump. Pressure values are extracted with ultrasound and a commercial piezoresistive pressure sensor is used for pressure validation. The porcine artery showed much more realistic stiffness values (·=15.360) than the silicon tube (·=543.420), which was very stiff in comparison to the typical in-vivo radial artery stiffness (·=9.5). The decrease in stiffness of 97.173 % (from the silicone tube to the porcine artery) led to an acute decrease in the derived pressure error. This work serves as guidelines for the development of a low-budget arm phantom, as the simple setup allowed for a primary validation of a proof-of-concept ultrasound-based sensor for the measurement of pressure.https://doi.org/10.1515/cdbme-2022-1049bp monitoringcufflessmimicked armstiffnessex-vivo validation |
| spellingShingle | Gonçalves Seabra Ana Carolina Ferreira da Silva Alexandre Stieglitz Thomas Belen Amado-Rey Ana Preliminary validation system for cuffless blood pressure measurement Current Directions in Biomedical Engineering bp monitoring cuffless mimicked arm stiffness ex-vivo validation |
| title | Preliminary validation system for cuffless blood pressure measurement |
| title_full | Preliminary validation system for cuffless blood pressure measurement |
| title_fullStr | Preliminary validation system for cuffless blood pressure measurement |
| title_full_unstemmed | Preliminary validation system for cuffless blood pressure measurement |
| title_short | Preliminary validation system for cuffless blood pressure measurement |
| title_sort | preliminary validation system for cuffless blood pressure measurement |
| topic | bp monitoring cuffless mimicked arm stiffness ex-vivo validation |
| url | https://doi.org/10.1515/cdbme-2022-1049 |
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