SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City
Abstract Objective To assess SARS-CoV-2 antibody prevalence and titers in people living with HIV (PLWHIV) on antiretroviral treatment (ART) enrolled at a tertiary reference hospital in Mexico. Methods Two plasma aliquots per person, used for HIV viral load follow-up between 01/2020 and 09/2021, were...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-023-02261-2 |
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| author | Maribel Soto-Nava Vanessa Dávila-Conn Juan P. Venancio-Rocha Pedro García-Esparza Daniela Tapia-Trejo Ramón Hernández-Juan Eduardo Zarza-Sánchez Akio Murakami-Ogasawara Santiago Ávila-Ríos |
| author_facet | Maribel Soto-Nava Vanessa Dávila-Conn Juan P. Venancio-Rocha Pedro García-Esparza Daniela Tapia-Trejo Ramón Hernández-Juan Eduardo Zarza-Sánchez Akio Murakami-Ogasawara Santiago Ávila-Ríos |
| author_sort | Maribel Soto-Nava |
| collection | DOAJ |
| description | Abstract Objective To assess SARS-CoV-2 antibody prevalence and titers in people living with HIV (PLWHIV) on antiretroviral treatment (ART) enrolled at a tertiary reference hospital in Mexico. Methods Two plasma aliquots per person, used for HIV viral load follow-up between 01/2020 and 09/2021, were used to assess total anti-N and neutralizing SARS-CoV-2 antibodies. Sociodemographic, clinical, and SARS-CoV-2 exposure risk information were collected. The risk associated with SARS-CoV-2 exposure and associations with antibody titers were analyzed with logistic, Cox, and linear multivariable models. Results 803 PLWHIV participated; 233 had detectable SARS-CoV-2 antibodies (prevalent cases), and 132 seroconverted (incident cases). Overall, the adjusted prevalence was 46.45%, with an incidence rate of 3.78 cases/100 person-months. Factors associated with prevalent cases included lower age, location (western zone of Mexico City and the neighboring Mexico State), use of public transport, attendance at meetings without social distancing, and higher CD4 + T cell counts (p < 0.05; multivariable logistic model). BNT162b2 vaccination reduced incident cases (Cox adjusted HR = 0.4; p = 0.013). Notably, previously infected and vaccinated individuals showed maximization of neutralizing activity (p < 0.001). No associations between SARS-CoV-2 neutralization and HIV-related variables (CD4 + T cell counts, viral load, number of years in viral suppression, ART regimen) were found in multivariable analysis. Conclusions SARS-CoV-2 infection was associated with community risk rather than HIV-associated variables in PLWH on ART and clinical follow-up. Antibody neutralization activity in vaccinated participants was maximized with previous SARS-CoV-2 infection. |
| first_indexed | 2024-03-08T22:41:09Z |
| format | Article |
| id | doaj.art-38afcb6c5ccf43e3acb183a2432f568e |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-03-08T22:41:09Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-38afcb6c5ccf43e3acb183a2432f568e2023-12-17T12:06:52ZengBMCVirology Journal1743-422X2023-12-0120111210.1186/s12985-023-02261-2SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico CityMaribel Soto-Nava0Vanessa Dávila-Conn1Juan P. Venancio-Rocha2Pedro García-Esparza3Daniela Tapia-Trejo4Ramón Hernández-Juan5Eduardo Zarza-Sánchez6Akio Murakami-Ogasawara7Santiago Ávila-Ríos8Centre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesCentre for Research in Infectious Diseases, National Institute of Respiratory DiseasesAbstract Objective To assess SARS-CoV-2 antibody prevalence and titers in people living with HIV (PLWHIV) on antiretroviral treatment (ART) enrolled at a tertiary reference hospital in Mexico. Methods Two plasma aliquots per person, used for HIV viral load follow-up between 01/2020 and 09/2021, were used to assess total anti-N and neutralizing SARS-CoV-2 antibodies. Sociodemographic, clinical, and SARS-CoV-2 exposure risk information were collected. The risk associated with SARS-CoV-2 exposure and associations with antibody titers were analyzed with logistic, Cox, and linear multivariable models. Results 803 PLWHIV participated; 233 had detectable SARS-CoV-2 antibodies (prevalent cases), and 132 seroconverted (incident cases). Overall, the adjusted prevalence was 46.45%, with an incidence rate of 3.78 cases/100 person-months. Factors associated with prevalent cases included lower age, location (western zone of Mexico City and the neighboring Mexico State), use of public transport, attendance at meetings without social distancing, and higher CD4 + T cell counts (p < 0.05; multivariable logistic model). BNT162b2 vaccination reduced incident cases (Cox adjusted HR = 0.4; p = 0.013). Notably, previously infected and vaccinated individuals showed maximization of neutralizing activity (p < 0.001). No associations between SARS-CoV-2 neutralization and HIV-related variables (CD4 + T cell counts, viral load, number of years in viral suppression, ART regimen) were found in multivariable analysis. Conclusions SARS-CoV-2 infection was associated with community risk rather than HIV-associated variables in PLWH on ART and clinical follow-up. Antibody neutralization activity in vaccinated participants was maximized with previous SARS-CoV-2 infection.https://doi.org/10.1186/s12985-023-02261-2SARS-CoV-2COVID-19SeroepidemiologyVaccinationAntibodyHIV |
| spellingShingle | Maribel Soto-Nava Vanessa Dávila-Conn Juan P. Venancio-Rocha Pedro García-Esparza Daniela Tapia-Trejo Ramón Hernández-Juan Eduardo Zarza-Sánchez Akio Murakami-Ogasawara Santiago Ávila-Ríos SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City Virology Journal SARS-CoV-2 COVID-19 Seroepidemiology Vaccination Antibody HIV |
| title | SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City |
| title_full | SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City |
| title_fullStr | SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City |
| title_full_unstemmed | SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City |
| title_short | SARSCoV-2 antibody prevalence and titers in persons living with HIV cared for at a large tertiary reference center in Mexico City |
| title_sort | sarscov 2 antibody prevalence and titers in persons living with hiv cared for at a large tertiary reference center in mexico city |
| topic | SARS-CoV-2 COVID-19 Seroepidemiology Vaccination Antibody HIV |
| url | https://doi.org/10.1186/s12985-023-02261-2 |
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