Free spermidine evokes superoxide radicals that manifest toxicity

Free spermidine evokes superoxide radicals that manifest toxicity

Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Thus, wild-type E. coli can tolerate applied exogenous spermidine stress, but ΔspeG strain o...

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Bibliographic Details
Main Authors: Vineet Kumar, Rajesh Kumar Mishra, Debarghya Ghose, Arunima Kalita, Pulkit Dhiman, Anand Prakash, Nirja Thakur, Gopa Mitra, Vinod D Chaudhari, Amit Arora, Dipak Dutta
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
Escherichia coli
SpeG
spermidine toxicity
superoxide radical
iron metabolism
oxidative stress
Online Access:https://elifesciences.org/articles/77704

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