LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma

LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma

Abstract Long non-coding RNAs (lncRNAs) play a crucial role in macrophage development but little is known about their role in asthma. Here, we investigated the role of lncRNA lncTRPM2-AS in asthma and found that lncTRPM2-AS participates in the promotion of macrophage inflammation. Downregulation of...

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Bibliographic Details
Main Authors: Xiaoping Li, Wenwen Wang, Yu Shao, Ji Zhou, Jiaqi Huang, Fei Xu, Xiu Gao, Mengyun Wu, Yongli Dong, Wenyan Wu, Jiamin Cai, Junyao Wang, Yunfei Ye, Zhengrong Chen, Chuangli Hao, Yi Yang, Jinping Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04437-6

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