HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

Abstract Background IGHV mutation status is a crucial prognostic biomarker for CLL. In the present study, we investigated the transcriptomic signatures associating with IGHV mutation status and CLL prognosis. Methods The co-expression modules and hub genes correlating with IGHV status, were identifi...

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Bibliographic Details
Main Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Translational Medicine
Subjects:
Chronic lymphocytic leukemia
Survival analysis
Gene expression profile
IGHV mutation
Online Access:https://doi.org/10.1186/s12967-021-02708-6

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