Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment
A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the phy...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2015-03-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.2.232 |
| _version_ | 1828149505827012608 |
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| author | Jeong Min Lee Yu Jin Kim |
| author_facet | Jeong Min Lee Yu Jin Kim |
| author_sort | Jeong Min Lee |
| collection | DOAJ |
| description | A foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities. |
| first_indexed | 2024-04-11T21:30:09Z |
| format | Article |
| id | doaj.art-38b29f15cf4c4eda82ccd8f0794e967a |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T21:30:09Z |
| publishDate | 2015-03-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-38b29f15cf4c4eda82ccd8f0794e967a2022-12-22T04:02:01ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712015-03-01420223223910.5999/aps.2015.42.2.232486Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and TreatmentJeong Min Lee0Yu Jin Kim1Department of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, Incheon, KoreaDepartment of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, Incheon, KoreaA foreign body granuloma is a non-allergic chronic inflammatory reaction that is mainly composed of multinucleated giant cells. Foreign body granulomas may occur after the administration of any dermal filler. Factors such as the volume of the injection, impurities present in the fillers, and the physical properties of fillers affect granuloma formation. The formation of granulomas involves five phases: protein adsorption, macrophage adhesion, macrophage fusion, and crosstalk. The clinical and pathologic features of granulomas vary depending on the type of filler that causes them. Foreign body granulomas can be treated effectively with intralesional corticosteroid injections. Surgical excisions of granulomas tend to be incomplete because granulomas have ill-defined borders and moreover, surgical excisions may leave scars and deformities.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.2.232granuloma, foreign-bodyhyaluronic acidcollagensilicone gels |
| spellingShingle | Jeong Min Lee Yu Jin Kim Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment Archives of Plastic Surgery granuloma, foreign-body hyaluronic acid collagen silicone gels |
| title | Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment |
| title_full | Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment |
| title_fullStr | Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment |
| title_full_unstemmed | Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment |
| title_short | Foreign Body Granulomas after the Use of Dermal Fillers: Pathophysiology, Clinical Appearance, Histologic Features, and Treatment |
| title_sort | foreign body granulomas after the use of dermal fillers pathophysiology clinical appearance histologic features and treatment |
| topic | granuloma, foreign-body hyaluronic acid collagen silicone gels |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.2.232 |
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