PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL
The review focuses on the gathered data related to preconditioning phenomenon and, particularly, pharmacological preconditioning of myocardium. The information presented, on the activator of ATP-dependent potassium channels nicorandil. Mechanism of action is discussed, as efficacy and safety data. T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2017-10-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2543 |
| _version_ | 1797856875407998976 |
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| author | R. V. Gostishchev G. N. Soboleva A. N. Samko A. G. Osiev |
| author_facet | R. V. Gostishchev G. N. Soboleva A. N. Samko A. G. Osiev |
| author_sort | R. V. Gostishchev |
| collection | DOAJ |
| description | The review focuses on the gathered data related to preconditioning phenomenon and, particularly, pharmacological preconditioning of myocardium. The information presented, on the activator of ATP-dependent potassium channels nicorandil. Mechanism of action is discussed, as efficacy and safety data. The evidence shows that, recently, nicorandil is not an obligatory medication to follow percutaneous intervention on coronary arteries, though clinical trials data confirm the possibility of periprocedural myocardium damage risk reduction, if the drug is prescribed in advance. The data presented, on positive influence of nicorandil on myocardial contractility and clinical outcomes. |
| first_indexed | 2024-04-09T20:47:36Z |
| format | Article |
| id | doaj.art-38b30ef13e424334bfda76593770acf0 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:47:36Z |
| publishDate | 2017-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-38b30ef13e424334bfda76593770acf02023-03-29T21:23:28Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-10-010811412110.15829/1560-4071-2017-8-114-1212253PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDILR. V. Gostishchev0G. N. Soboleva1A. N. Samko2A. G. Osiev3National Medical Research Center for CardiologyNational Medical Research Center for CardiologyNational Medical Research Center for CardiologyMoscow Regional Research and Clinical Institute (MONIKI)The review focuses on the gathered data related to preconditioning phenomenon and, particularly, pharmacological preconditioning of myocardium. The information presented, on the activator of ATP-dependent potassium channels nicorandil. Mechanism of action is discussed, as efficacy and safety data. The evidence shows that, recently, nicorandil is not an obligatory medication to follow percutaneous intervention on coronary arteries, though clinical trials data confirm the possibility of periprocedural myocardium damage risk reduction, if the drug is prescribed in advance. The data presented, on positive influence of nicorandil on myocardial contractility and clinical outcomes.https://russjcardiol.elpub.ru/jour/article/view/2543pharmacological preconditioning of myocardiumnicorandilactivator of atp-dependent potassium channelspercutaneous coronary interventionscardiac enzymes |
| spellingShingle | R. V. Gostishchev G. N. Soboleva A. N. Samko A. G. Osiev PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL Российский кардиологический журнал pharmacological preconditioning of myocardium nicorandil activator of atp-dependent potassium channels percutaneous coronary interventions cardiac enzymes |
| title | PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL |
| title_full | PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL |
| title_fullStr | PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL |
| title_full_unstemmed | PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL |
| title_short | PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL |
| title_sort | pharmacological preconditioning focus on nicorandil |
| topic | pharmacological preconditioning of myocardium nicorandil activator of atp-dependent potassium channels percutaneous coronary interventions cardiac enzymes |
| url | https://russjcardiol.elpub.ru/jour/article/view/2543 |
| work_keys_str_mv | AT rvgostishchev pharmacologicalpreconditioningfocusonnicorandil AT gnsoboleva pharmacologicalpreconditioningfocusonnicorandil AT ansamko pharmacologicalpreconditioningfocusonnicorandil AT agosiev pharmacologicalpreconditioningfocusonnicorandil |