Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study
Purpose. A single-institution prospective pilot study was conducted to the assess correlation between salivary amylase and xerostomia in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT). Methods and materials. Serum saliva amylase, clin...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/9/516 |
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| author | Francesca De Felice Maria Giulia Scarabelli Raffaella De Pietro Giuseppina Chiarello Federico Di Giammarco Carlo Guglielmo Cattaneo Giuliana Lombardo Francesca Romana Montinaro Miriam Tomaciello Mario Tombolini Daniela Messineo Pier Luigi Di Paolo Claudia Marchetti Daniela Musio Vincenzo Tombolini |
| author_facet | Francesca De Felice Maria Giulia Scarabelli Raffaella De Pietro Giuseppina Chiarello Federico Di Giammarco Carlo Guglielmo Cattaneo Giuliana Lombardo Francesca Romana Montinaro Miriam Tomaciello Mario Tombolini Daniela Messineo Pier Luigi Di Paolo Claudia Marchetti Daniela Musio Vincenzo Tombolini |
| author_sort | Francesca De Felice |
| collection | DOAJ |
| description | Purpose. A single-institution prospective pilot study was conducted to the assess correlation between salivary amylase and xerostomia in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT). Methods and materials. Serum saliva amylase, clinician-reported xerostomia (using Common Terminology Criteria for Adverse Events), and patient-reported xerostomia (using 8-item self-reported xerostomia-specific questionnaire) were prospectively collected at baseline, during treatment and thereafter. Correlations between variables were assessed by correlation matrices. Results. Twelve patients with locally advanced HNSCC formed the cohort. Eighty-three percent were male, 75% were smokers, 100% had clinical positive lymph nodes at diagnosis, and 42% received induction chemotherapy. All patients received IMRT with concurrent cisplatin-based chemotherapy. No grade ≥4 xerostomia was observed. Severe (G3) acute and late xerostomia occurred in five cases (41.7%) and two cases (16.7%), respectively. Patient-reported xerostomia scores were highly correlated with the clinician-reported scores (ρ = 0.73). A significant correlation was recorded between the concentration of amylase and the acute (ρ = −0.70) and late (ρ = −0.80) xerostomia. Conclusion. Preliminary results are encouraging. Prospective clinical trials are needed to define the value of salivary amylase in the management of HNSCC tumors. |
| first_indexed | 2024-03-10T00:18:43Z |
| format | Article |
| id | doaj.art-38b3fb8e22ae4f77933b09dcc5815208 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T00:18:43Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-38b3fb8e22ae4f77933b09dcc58152082023-11-23T15:46:09ZengMDPI AGCurrent Oncology1198-00521718-77292022-09-012996564657210.3390/curroncol29090516Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot StudyFrancesca De Felice0Maria Giulia Scarabelli1Raffaella De Pietro2Giuseppina Chiarello3Federico Di Giammarco4Carlo Guglielmo Cattaneo5Giuliana Lombardo6Francesca Romana Montinaro7Miriam Tomaciello8Mario Tombolini9Daniela Messineo10Pier Luigi Di Paolo11Claudia Marchetti12Daniela Musio13Vincenzo Tombolini14Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral and Maxillo Facial Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Imaging, IRCCS Ospedale Pediatrico Bambino Gesù, 00165 Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyPurpose. A single-institution prospective pilot study was conducted to the assess correlation between salivary amylase and xerostomia in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiotherapy (IMRT). Methods and materials. Serum saliva amylase, clinician-reported xerostomia (using Common Terminology Criteria for Adverse Events), and patient-reported xerostomia (using 8-item self-reported xerostomia-specific questionnaire) were prospectively collected at baseline, during treatment and thereafter. Correlations between variables were assessed by correlation matrices. Results. Twelve patients with locally advanced HNSCC formed the cohort. Eighty-three percent were male, 75% were smokers, 100% had clinical positive lymph nodes at diagnosis, and 42% received induction chemotherapy. All patients received IMRT with concurrent cisplatin-based chemotherapy. No grade ≥4 xerostomia was observed. Severe (G3) acute and late xerostomia occurred in five cases (41.7%) and two cases (16.7%), respectively. Patient-reported xerostomia scores were highly correlated with the clinician-reported scores (ρ = 0.73). A significant correlation was recorded between the concentration of amylase and the acute (ρ = −0.70) and late (ρ = −0.80) xerostomia. Conclusion. Preliminary results are encouraging. Prospective clinical trials are needed to define the value of salivary amylase in the management of HNSCC tumors.https://www.mdpi.com/1718-7729/29/9/516salivary amylasexerostomiaparotidsalivary glandIMRTradiotherapy |
| spellingShingle | Francesca De Felice Maria Giulia Scarabelli Raffaella De Pietro Giuseppina Chiarello Federico Di Giammarco Carlo Guglielmo Cattaneo Giuliana Lombardo Francesca Romana Montinaro Miriam Tomaciello Mario Tombolini Daniela Messineo Pier Luigi Di Paolo Claudia Marchetti Daniela Musio Vincenzo Tombolini Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study Current Oncology salivary amylase xerostomia parotid salivary gland IMRT radiotherapy |
| title | Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study |
| title_full | Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study |
| title_fullStr | Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study |
| title_full_unstemmed | Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study |
| title_short | Relationship between Salivary Amylase and Xerostomia in Intensity-Modulated Radiation Therapy for Head and Neck Cancer: A Prospective Pilot Study |
| title_sort | relationship between salivary amylase and xerostomia in intensity modulated radiation therapy for head and neck cancer a prospective pilot study |
| topic | salivary amylase xerostomia parotid salivary gland IMRT radiotherapy |
| url | https://www.mdpi.com/1718-7729/29/9/516 |
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