Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms
Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico...
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/6/2008 |
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| author | Delia Sansores-España Alfredo Geovanny Pech-Aguilar Karol Guadalupe Cua-Pech Isabel Medina-Vera Martha Guevara-Cruz Ana Ligia Gutiérrez-Solis Juan G. Reyes-García Azalia Avila-Nava |
| author_facet | Delia Sansores-España Alfredo Geovanny Pech-Aguilar Karol Guadalupe Cua-Pech Isabel Medina-Vera Martha Guevara-Cruz Ana Ligia Gutiérrez-Solis Juan G. Reyes-García Azalia Avila-Nava |
| author_sort | Delia Sansores-España |
| collection | DOAJ |
| description | Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as <i>Argemone mexicana</i> L., <i>Berberis trifoliata Hartw. ex Lindl.</i>, <i>Costus mexicanus Liebm</i>, <i>Chenopodium album</i> L., <i>Ammi visnaga</i> (L.) <i>Lam.</i>, <i>Eysenhardtia polystachya</i> (<i>Ortega</i>) <i>Sarg.</i>, <i>Selaginella lepidophylla</i> (<i>Hook. & Grev.</i>) <i>Spring</i>, and <i>Taraxacum officinale</i> L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL. |
| first_indexed | 2024-03-09T13:08:27Z |
| format | Article |
| id | doaj.art-38b4f33c500840afa7341540aed9639f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T13:08:27Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-38b4f33c500840afa7341540aed9639f2023-11-30T21:44:33ZengMDPI AGMolecules1420-30492022-03-01276200810.3390/molecules27062008Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular MechanismsDelia Sansores-España0Alfredo Geovanny Pech-Aguilar1Karol Guadalupe Cua-Pech2Isabel Medina-Vera3Martha Guevara-Cruz4Ana Ligia Gutiérrez-Solis5Juan G. Reyes-García6Azalia Avila-Nava7Sección de estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Yucatán, Mérida 97130, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Yucatán, Mérida 97130, MexicoDepartamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México 04530, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México 14380, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Yucatán, Mérida 97130, MexicoSección de estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoHospital Regional de Alta Especialidad de la Península de Yucatán, Yucatán, Mérida 97130, MexicoUrolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as <i>Argemone mexicana</i> L., <i>Berberis trifoliata Hartw. ex Lindl.</i>, <i>Costus mexicanus Liebm</i>, <i>Chenopodium album</i> L., <i>Ammi visnaga</i> (L.) <i>Lam.</i>, <i>Eysenhardtia polystachya</i> (<i>Ortega</i>) <i>Sarg.</i>, <i>Selaginella lepidophylla</i> (<i>Hook. & Grev.</i>) <i>Spring</i>, and <i>Taraxacum officinale</i> L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.https://www.mdpi.com/1420-3049/27/6/2008urinary stonesMexicotraditional plantsbioactive compounds |
| spellingShingle | Delia Sansores-España Alfredo Geovanny Pech-Aguilar Karol Guadalupe Cua-Pech Isabel Medina-Vera Martha Guevara-Cruz Ana Ligia Gutiérrez-Solis Juan G. Reyes-García Azalia Avila-Nava Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms Molecules urinary stones Mexico traditional plants bioactive compounds |
| title | Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms |
| title_full | Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms |
| title_fullStr | Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms |
| title_full_unstemmed | Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms |
| title_short | Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms |
| title_sort | plants used in mexican traditional medicine for the management of urolithiasis a review of preclinical evidence bioactive compounds and molecular mechanisms |
| topic | urinary stones Mexico traditional plants bioactive compounds |
| url | https://www.mdpi.com/1420-3049/27/6/2008 |
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