The other side of cardiac Ca2+ signaling: transcriptional control
Ca2+ is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca2+ is not only a key element in excitation-contraction coupling (EC coupling), but it is also a pivotal second mes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00452/full |
| _version_ | 1811253783741595648 |
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| author | Alejandro eDomínguez-Rodríquez Gema eRuiz-Hurtado Jean-Pierre eBenitah Ana M Gomez |
| author_facet | Alejandro eDomínguez-Rodríquez Gema eRuiz-Hurtado Jean-Pierre eBenitah Ana M Gomez |
| author_sort | Alejandro eDomínguez-Rodríquez |
| collection | DOAJ |
| description | Ca2+ is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca2+ is not only a key element in excitation-contraction coupling (EC coupling), but it is also a pivotal second messenger in cardiac signal transduction, being able to control processes such as excitability, metabolism, and transcriptional regulation. Regarding the latter, Ca2+ activates Ca2+-dependent transcription factors by a process called excitation-transcription coupling (ET coupling). ET coupling is an integrated process by which the common signaling pathways that regulate EC coupling activate transcription factors. Although ET coupling has been extensively studied in neurons and other cell types, less is known in cardiac muscle. Some hints have been found in studies on the development of cardiac hypertrophy, where two Ca2+-dependent enzymes are key actors: Ca2+/Calmodulin kinase II (CaMKII) and phosphatase calcineurin, both of which are activated by the complex Ca2+/ /Calmodulin. The question now is how ET coupling occurs in cardiomyocytes, where intracellular Ca2+ is continuously oscillating. In this focused review, we will draw attention to location of Ca2+ signaling: intranuclear ([Ca2+]n) or cytoplasmic ([Ca2+]c), and the specific ionic channels involved in the activation of cardiac ET coupling. Specifically, we will highlight the role of the 1,4,5 inositol triphosphate receptors (IP3Rs) in the elevation of [Ca2+]n levels, which are important to locally activate CaMKII, and the role of transient receptor potential channels canonical (TRPCs) in [Ca2+]c, needed to activate calcineurin. |
| first_indexed | 2024-04-12T16:56:25Z |
| format | Article |
| id | doaj.art-38b57393b44749bfac9df652d0d85778 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T16:56:25Z |
| publishDate | 2012-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-38b57393b44749bfac9df652d0d857782022-12-22T03:24:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-11-01310.3389/fphys.2012.0045227409The other side of cardiac Ca2+ signaling: transcriptional controlAlejandro eDomínguez-Rodríquez0Gema eRuiz-Hurtado1Jean-Pierre eBenitah2Ana M Gomez3INSERMINSERMINSERMINSERMCa2+ is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca2+ is not only a key element in excitation-contraction coupling (EC coupling), but it is also a pivotal second messenger in cardiac signal transduction, being able to control processes such as excitability, metabolism, and transcriptional regulation. Regarding the latter, Ca2+ activates Ca2+-dependent transcription factors by a process called excitation-transcription coupling (ET coupling). ET coupling is an integrated process by which the common signaling pathways that regulate EC coupling activate transcription factors. Although ET coupling has been extensively studied in neurons and other cell types, less is known in cardiac muscle. Some hints have been found in studies on the development of cardiac hypertrophy, where two Ca2+-dependent enzymes are key actors: Ca2+/Calmodulin kinase II (CaMKII) and phosphatase calcineurin, both of which are activated by the complex Ca2+/ /Calmodulin. The question now is how ET coupling occurs in cardiomyocytes, where intracellular Ca2+ is continuously oscillating. In this focused review, we will draw attention to location of Ca2+ signaling: intranuclear ([Ca2+]n) or cytoplasmic ([Ca2+]c), and the specific ionic channels involved in the activation of cardiac ET coupling. Specifically, we will highlight the role of the 1,4,5 inositol triphosphate receptors (IP3Rs) in the elevation of [Ca2+]n levels, which are important to locally activate CaMKII, and the role of transient receptor potential channels canonical (TRPCs) in [Ca2+]c, needed to activate calcineurin.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00452/fullCalciumHeartTRPCexcitation-transcription couplingnuclear calcium |
| spellingShingle | Alejandro eDomínguez-Rodríquez Gema eRuiz-Hurtado Jean-Pierre eBenitah Ana M Gomez The other side of cardiac Ca2+ signaling: transcriptional control Frontiers in Physiology Calcium Heart TRPC excitation-transcription coupling nuclear calcium |
| title | The other side of cardiac Ca2+ signaling: transcriptional control |
| title_full | The other side of cardiac Ca2+ signaling: transcriptional control |
| title_fullStr | The other side of cardiac Ca2+ signaling: transcriptional control |
| title_full_unstemmed | The other side of cardiac Ca2+ signaling: transcriptional control |
| title_short | The other side of cardiac Ca2+ signaling: transcriptional control |
| title_sort | other side of cardiac ca2 signaling transcriptional control |
| topic | Calcium Heart TRPC excitation-transcription coupling nuclear calcium |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00452/full |
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