Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187892932300018X |
| _version_ | 1797843833570983936 |
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| author | Aiden Ford Zsofia A. Kovacs-Balint Arick Wang Eric Feczko Eric Earl Óscar Miranda-Domínguez Longchuan Li Martin Styner Damien Fair Warren Jones Jocelyne Bachevalier Mar M. Sánchez |
| author_facet | Aiden Ford Zsofia A. Kovacs-Balint Arick Wang Eric Feczko Eric Earl Óscar Miranda-Domínguez Longchuan Li Martin Styner Damien Fair Warren Jones Jocelyne Bachevalier Mar M. Sánchez |
| author_sort | Aiden Ford |
| collection | DOAJ |
| description | Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy. |
| first_indexed | 2024-04-09T17:13:35Z |
| format | Article |
| id | doaj.art-38b5be3b3102448ab16ad5cfafbc8f94 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-09T17:13:35Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-38b5be3b3102448ab16ad5cfafbc8f942023-04-20T04:36:06ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-04-0160101213Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social statusAiden Ford0Zsofia A. Kovacs-Balint1Arick Wang2Eric Feczko3Eric Earl4Óscar Miranda-Domínguez5Longchuan Li6Martin Styner7Damien Fair8Warren Jones9Jocelyne Bachevalier10Mar M. Sánchez11Neuroscience Program, Emory University, Atlanta, GA, USA; Marcus Autism Center, USA; Correspondence to: Marcus Autism Center, Emory University, 1920 Briarcliff Rd NE, Atlanta, GA 30329, USA.Emory Natl. Primate Res. Ctr., Emory Univ., Atlanta, GA, USAEmory Natl. Primate Res. Ctr., Emory Univ., Atlanta, GA, USA; Dept of Psychology, Emory University, Atlanta, GA, USADept. of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute of the Developing Brain, University of Minnesota, Minneapolis, MN, USAData Science and Sharing Team, National Institute of Mental Health, NIH, DHHS, Bethesda, MD, USADept. of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute of the Developing Brain, University of Minnesota, Minneapolis, MN, USAMarcus Autism Center, USA; Children’s Healthcare of Atlanta, GA, USA; Dept. of Pediatrics, Emory University, Sch. of Med., Atlanta, GA, USADept. of Psychiatry, Univ. of North Carolina, Chapel Hill, NC, USADept. of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute of the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA; Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USAMarcus Autism Center, USA; Children’s Healthcare of Atlanta, GA, USA; Dept. of Pediatrics, Emory University, Sch. of Med., Atlanta, GA, USAEmory Natl. Primate Res. Ctr., Emory Univ., Atlanta, GA, USA; Dept of Psychology, Emory University, Atlanta, GA, USAEmory Natl. Primate Res. Ctr., Emory Univ., Atlanta, GA, USA; Dept. Psychiatry & Behavioral Sciences, Emory Univ., Sch. of Med., Atlanta, GA, USADifferences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy.http://www.sciencedirect.com/science/article/pii/S187892932300018XNonhuman primateInfant developmentSocial attentionVisual object pathwayBrain-behavior associationsResting state fMRI |
| spellingShingle | Aiden Ford Zsofia A. Kovacs-Balint Arick Wang Eric Feczko Eric Earl Óscar Miranda-Domínguez Longchuan Li Martin Styner Damien Fair Warren Jones Jocelyne Bachevalier Mar M. Sánchez Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status Developmental Cognitive Neuroscience Nonhuman primate Infant development Social attention Visual object pathway Brain-behavior associations Resting state fMRI |
| title | Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status |
| title_full | Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status |
| title_fullStr | Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status |
| title_full_unstemmed | Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status |
| title_short | Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status |
| title_sort | functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques effects of social status |
| topic | Nonhuman primate Infant development Social attention Visual object pathway Brain-behavior associations Resting state fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S187892932300018X |
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