Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon
The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produ...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-02-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/73675 |
| _version_ | 1797998429647929344 |
|---|---|
| author | Alejandro Peñin-Franch José Antonio García-Vidal Carlos Manuel Martínez Pilar Escolar-Reina Rosa M Martínez-Ojeda Ana I Gómez Juan M Bueno Francisco Minaya-Muñoz Fermín Valera-Garrido Francesc Medina-Mirapeix Pablo Pelegrín |
| author_facet | Alejandro Peñin-Franch José Antonio García-Vidal Carlos Manuel Martínez Pilar Escolar-Reina Rosa M Martínez-Ojeda Ana I Gómez Juan M Bueno Francisco Minaya-Muñoz Fermín Valera-Garrido Francesc Medina-Mirapeix Pablo Pelegrín |
| author_sort | Alejandro Peñin-Franch |
| collection | DOAJ |
| description | The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response. |
| first_indexed | 2024-04-11T10:48:37Z |
| format | Article |
| id | doaj.art-38b6aac499bd49c3b6b004cde44e8443 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:48:37Z |
| publishDate | 2022-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-38b6aac499bd49c3b6b004cde44e84432022-12-22T04:28:58ZengeLife Sciences Publications LtdeLife2050-084X2022-02-011110.7554/eLife.73675Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendonAlejandro Peñin-Franch0https://orcid.org/0000-0001-5329-1671José Antonio García-Vidal1Carlos Manuel Martínez2https://orcid.org/0000-0003-3307-1326Pilar Escolar-Reina3Rosa M Martínez-Ojeda4Ana I Gómez5Juan M Bueno6Francisco Minaya-Muñoz7Fermín Valera-Garrido8https://orcid.org/0000-0002-8867-2519Francesc Medina-Mirapeix9Pablo Pelegrín10https://orcid.org/0000-0002-9688-1804Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; Department of Physical Therapy, University of Murcia, Murcia, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; Department of Physical Therapy, University of Murcia, Murcia, SpainLaboratorio de Óptica, Instituto Universitario de Investigación en Óptica y Nanofísica, Universidad de Murcia, Murcia, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, SpainLaboratorio de Óptica, Instituto Universitario de Investigación en Óptica y Nanofísica, Universidad de Murcia, Murcia, SpainCEU San Pablo University, Madrid, Spain; MVClinic Institute, Madrid, SpainCEU San Pablo University, Madrid, Spain; MVClinic Institute, Madrid, Spain; Invasive Physiotherapy Department, Getafe C.F, Madrid, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; Department of Physical Therapy, University of Murcia, Murcia, SpainInstituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain; Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, SpainThe NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response.https://elifesciences.org/articles/73675percutaneous needle electrolysistendontendinopathyinflammasomeNLRP3caspase-1 |
| spellingShingle | Alejandro Peñin-Franch José Antonio García-Vidal Carlos Manuel Martínez Pilar Escolar-Reina Rosa M Martínez-Ojeda Ana I Gómez Juan M Bueno Francisco Minaya-Muñoz Fermín Valera-Garrido Francesc Medina-Mirapeix Pablo Pelegrín Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon eLife percutaneous needle electrolysis tendon tendinopathy inflammasome NLRP3 caspase-1 |
| title | Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |
| title_full | Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |
| title_fullStr | Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |
| title_full_unstemmed | Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |
| title_short | Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |
| title_sort | galvanic current activates the nlrp3 inflammasome to promote type i collagen production in tendon |
| topic | percutaneous needle electrolysis tendon tendinopathy inflammasome NLRP3 caspase-1 |
| url | https://elifesciences.org/articles/73675 |
| work_keys_str_mv | AT alejandropeninfranch galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT joseantoniogarciavidal galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT carlosmanuelmartinez galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT pilarescolarreina galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT rosammartinezojeda galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT anaigomez galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT juanmbueno galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT franciscominayamunoz galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT ferminvaleragarrido galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT francescmedinamirapeix galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon AT pablopelegrin galvaniccurrentactivatesthenlrp3inflammasometopromotetypeicollagenproductionintendon |