P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance
P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00632-2 |
| _version_ | 1818400516520017920 |
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| author | Raphael Loll-Krippleber Grant W. Brown |
| author_facet | Raphael Loll-Krippleber Grant W. Brown |
| author_sort | Raphael Loll-Krippleber |
| collection | DOAJ |
| description | P-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts. |
| first_indexed | 2024-12-14T07:37:49Z |
| format | Article |
| id | doaj.art-38b91d8a311c4ba5b0dd936cdd11a4b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:37:49Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-38b91d8a311c4ba5b0dd936cdd11a4b62022-12-21T23:11:08ZengNature PortfolioNature Communications2041-17232017-09-018111510.1038/s41467-017-00632-2P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistanceRaphael Loll-Krippleber0Grant W. Brown1Department of Biochemistry and Donnelly Centre, University of TorontoDepartment of Biochemistry and Donnelly Centre, University of TorontoP-bodies form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts.https://doi.org/10.1038/s41467-017-00632-2 |
| spellingShingle | Raphael Loll-Krippleber Grant W. Brown P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance Nature Communications |
| title | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance |
| title_full | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance |
| title_fullStr | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance |
| title_full_unstemmed | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance |
| title_short | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance |
| title_sort | p body proteins regulate transcriptional rewiring to promote dna replication stress resistance |
| url | https://doi.org/10.1038/s41467-017-00632-2 |
| work_keys_str_mv | AT raphaellollkrippleber pbodyproteinsregulatetranscriptionalrewiringtopromotednareplicationstressresistance AT grantwbrown pbodyproteinsregulatetranscriptionalrewiringtopromotednareplicationstressresistance |