FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats
Pain is an unpleasant subjective experience that is usually modified by complex multidimensional neuropsychological processes. Increasing numbers of neuroimaging studies in humans have characterized the hierarchical brain areas forming a pain matrix, which is involved in the different dimensions of...
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/63 |
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| author | Yilong Cui Hiroyuki Neyama Di Hu Tianliang Huang Emi Hayashinaka Yasuhiro Wada Yasuyoshi Watanabe |
| author_facet | Yilong Cui Hiroyuki Neyama Di Hu Tianliang Huang Emi Hayashinaka Yasuhiro Wada Yasuyoshi Watanabe |
| author_sort | Yilong Cui |
| collection | DOAJ |
| description | Pain is an unpleasant subjective experience that is usually modified by complex multidimensional neuropsychological processes. Increasing numbers of neuroimaging studies in humans have characterized the hierarchical brain areas forming a pain matrix, which is involved in the different dimensions of pain components. Although mechanistic investigations have been performed extensively in rodents, the homologous brain regions involved in the multidimensional pain components have not been fully understood in the rodent brain. Herein, we successfully identified several brain regions activated in response to mechanical allodynia in neuropathic pain rat models using an alternative neuroimaging method based on 2-deoxy-2-[<sup>18</sup>F]fluoro-<span style="font-variant: small-caps;">d</span>-glucose positron emission tomography (FDG PET) scanning. Regions such as the medial prefrontal cortex, primary somatosensory cortex hindlimb region, and the centrolateral thalamic nucleus were identified. Moreover, brain activity in these regions was positively correlated with mechanical allodynia-related behavioral changes. These results suggest that FDG PET imaging in neuropathic pain model rats enables the evaluation of regional brain activity encoding the multidimensional pain aspect. It could thus be a fascinating tool to bridge the gap between preclinical and clinical investigations. |
| first_indexed | 2024-03-09T13:30:02Z |
| format | Article |
| id | doaj.art-38b95e57f0d54fbaaf0f39ff83e34072 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:02Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-38b95e57f0d54fbaaf0f39ff83e340722023-11-30T21:18:55ZengMDPI AGBiomedicines2227-90592022-12-011116310.3390/biomedicines11010063FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model RatsYilong Cui0Hiroyuki Neyama1Di Hu2Tianliang Huang3Emi Hayashinaka4Yasuhiro Wada5Yasuyoshi Watanabe6Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanLaboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, JapanPain is an unpleasant subjective experience that is usually modified by complex multidimensional neuropsychological processes. Increasing numbers of neuroimaging studies in humans have characterized the hierarchical brain areas forming a pain matrix, which is involved in the different dimensions of pain components. Although mechanistic investigations have been performed extensively in rodents, the homologous brain regions involved in the multidimensional pain components have not been fully understood in the rodent brain. Herein, we successfully identified several brain regions activated in response to mechanical allodynia in neuropathic pain rat models using an alternative neuroimaging method based on 2-deoxy-2-[<sup>18</sup>F]fluoro-<span style="font-variant: small-caps;">d</span>-glucose positron emission tomography (FDG PET) scanning. Regions such as the medial prefrontal cortex, primary somatosensory cortex hindlimb region, and the centrolateral thalamic nucleus were identified. Moreover, brain activity in these regions was positively correlated with mechanical allodynia-related behavioral changes. These results suggest that FDG PET imaging in neuropathic pain model rats enables the evaluation of regional brain activity encoding the multidimensional pain aspect. It could thus be a fascinating tool to bridge the gap between preclinical and clinical investigations.https://www.mdpi.com/2227-9059/11/1/63neuroimagingFDGneuropathic painobjective biomarkerpain matrixpreclinic |
| spellingShingle | Yilong Cui Hiroyuki Neyama Di Hu Tianliang Huang Emi Hayashinaka Yasuhiro Wada Yasuyoshi Watanabe FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats Biomedicines neuroimaging FDG neuropathic pain objective biomarker pain matrix preclinic |
| title | FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats |
| title_full | FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats |
| title_fullStr | FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats |
| title_full_unstemmed | FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats |
| title_short | FDG PET Imaging of the Pain Matrix in Neuropathic Pain Model Rats |
| title_sort | fdg pet imaging of the pain matrix in neuropathic pain model rats |
| topic | neuroimaging FDG neuropathic pain objective biomarker pain matrix preclinic |
| url | https://www.mdpi.com/2227-9059/11/1/63 |
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