The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases
Chronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/4/1318 |
| _version_ | 1797537441761984512 |
|---|---|
| author | Tarek Benameur Raffaella Soleti Chiara Porro |
| author_facet | Tarek Benameur Raffaella Soleti Chiara Porro |
| author_sort | Tarek Benameur |
| collection | DOAJ |
| description | Chronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant production of pro-inflammatory cytokines leading to an increasing neuronal cell death. The decreased neuroinflammation could be obtained by using natural compounds, including flavonoids known to modulate the inflammatory responses. Among flavonoids, quercetin possess multiple pharmacological applications including anti-inflammatory, antitumoral, antiapoptotic and anti-thrombotic activities, widely demonstrated in both in vitro and in vivo studies. In this review, we describe the recent findings about the neuroprotective action of quercetin by acting with different mechanisms on the microglial cells of CNS. The ability of quercetin to influence microRNA expression represents an interesting skill in the regulation of inflammation, differentiation, proliferation, apoptosis and immune responses. Moreover, in order to enhance quercetin bioavailability and capacity to target the brain, we discuss an innovative drug delivery system. In summary, this review highlighted an important application of quercetin in the modulation of neuroinflammation and prevention of neurological disorders. |
| first_indexed | 2024-03-10T12:15:13Z |
| format | Article |
| id | doaj.art-38bc2d90d5124c8b919b33708095dfad |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:15:13Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-38bc2d90d5124c8b919b33708095dfad2023-11-21T15:52:16ZengMDPI AGNutrients2072-66432021-04-01134131810.3390/nu13041318The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological DiseasesTarek Benameur0Raffaella Soleti1Chiara Porro2College of Medicine, Department of Biomedical Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaUniv Angers, Université de Nantes, Inserm, CRCINA, SFR ICAT, F-49800 Angers, FranceDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyChronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant production of pro-inflammatory cytokines leading to an increasing neuronal cell death. The decreased neuroinflammation could be obtained by using natural compounds, including flavonoids known to modulate the inflammatory responses. Among flavonoids, quercetin possess multiple pharmacological applications including anti-inflammatory, antitumoral, antiapoptotic and anti-thrombotic activities, widely demonstrated in both in vitro and in vivo studies. In this review, we describe the recent findings about the neuroprotective action of quercetin by acting with different mechanisms on the microglial cells of CNS. The ability of quercetin to influence microRNA expression represents an interesting skill in the regulation of inflammation, differentiation, proliferation, apoptosis and immune responses. Moreover, in order to enhance quercetin bioavailability and capacity to target the brain, we discuss an innovative drug delivery system. In summary, this review highlighted an important application of quercetin in the modulation of neuroinflammation and prevention of neurological disorders.https://www.mdpi.com/2072-6643/13/4/1318quercetinnatural flavonoidneuroinflammationmicroglial cellsmiRNAneuroprotection |
| spellingShingle | Tarek Benameur Raffaella Soleti Chiara Porro The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases Nutrients quercetin natural flavonoid neuroinflammation microglial cells miRNA neuroprotection |
| title | The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases |
| title_full | The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases |
| title_fullStr | The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases |
| title_full_unstemmed | The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases |
| title_short | The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases |
| title_sort | potential neuroprotective role of free and encapsulated quercetin mediated by mirna against neurological diseases |
| topic | quercetin natural flavonoid neuroinflammation microglial cells miRNA neuroprotection |
| url | https://www.mdpi.com/2072-6643/13/4/1318 |
| work_keys_str_mv | AT tarekbenameur thepotentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases AT raffaellasoleti thepotentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases AT chiaraporro thepotentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases AT tarekbenameur potentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases AT raffaellasoleti potentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases AT chiaraporro potentialneuroprotectiveroleoffreeandencapsulatedquercetinmediatedbymirnaagainstneurologicaldiseases |