CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS
The paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2015-03-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/353 |
| Summary: | The paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left lung (C1-2) of the former patient. The female patient was operated on. M. tuberculosis DNA was identified by PCR in her intraoperative specimen; isoniazid and rifampicin resistance was determined. Occult multidrug resistance was a reason for ineffective treatment with first-line drugs. After 6-month chemotherapy, the size of a focus in the right left (C1-2) doubled and a new focal shadow emerged in the lung of the latter patient. The progression was related to the untimely obtained information on a broad drug resistance in the infection pathogen and to the chemotherapy performed by ignoring these data. Chemotherapy correction in view of the data of a drug susceptibility test could provide a positive result in both cases. |
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| ISSN: | 2075-1230 2542-1506 |