CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS
The paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left l...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2015-03-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/353 |
| _version_ | 1797696744429977600 |
|---|---|
| author | M. F. Gubkina N. V. Yukhimenko Yu. Yu. Khokhlova I. Yu. Petrakova S. G. Mikhailov |
| author_facet | M. F. Gubkina N. V. Yukhimenko Yu. Yu. Khokhlova I. Yu. Petrakova S. G. Mikhailov |
| author_sort | M. F. Gubkina |
| collection | DOAJ |
| description | The paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left lung (C1-2) of the former patient. The female patient was operated on. M. tuberculosis DNA was identified by PCR in her intraoperative specimen; isoniazid and rifampicin resistance was determined. Occult multidrug resistance was a reason for ineffective treatment with first-line drugs. After 6-month chemotherapy, the size of a focus in the right left (C1-2) doubled and a new focal shadow emerged in the lung of the latter patient. The progression was related to the untimely obtained information on a broad drug resistance in the infection pathogen and to the chemotherapy performed by ignoring these data. Chemotherapy correction in view of the data of a drug susceptibility test could provide a positive result in both cases. |
| first_indexed | 2024-03-12T03:30:40Z |
| format | Article |
| id | doaj.art-38bd4c2f66174b35bbf25e1c84885e01 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T03:30:40Z |
| publishDate | 2015-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-38bd4c2f66174b35bbf25e1c84885e012023-09-03T13:28:59ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-03-01035256353CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSISM. F. Gubkina0N. V. Yukhimenko1Yu. Yu. Khokhlova2I. Yu. Petrakova3S. G. Mikhailov4ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН, г. МоскваФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН, г. МоскваФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН, г. МоскваФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН, г. МоскваФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН, г. МоскваThe paper describes two clinical cases of progressive focal pulmonary tuberculosis in 11- and 12-year-old children. Chemotherapy regimen III was used because of the absence of bacterial excretion and the mild involvement of lung tissue. Following 4-month therapy, a focal decay appeared in the left lung (C1-2) of the former patient. The female patient was operated on. M. tuberculosis DNA was identified by PCR in her intraoperative specimen; isoniazid and rifampicin resistance was determined. Occult multidrug resistance was a reason for ineffective treatment with first-line drugs. After 6-month chemotherapy, the size of a focus in the right left (C1-2) doubled and a new focal shadow emerged in the lung of the latter patient. The progression was related to the untimely obtained information on a broad drug resistance in the infection pathogen and to the chemotherapy performed by ignoring these data. Chemotherapy correction in view of the data of a drug susceptibility test could provide a positive result in both cases.https://www.tibl-journal.com/jour/article/view/353очаговый туберкулез легкихмножественная лекарственная устойчивость микобактерий туберкулеза |
| spellingShingle | M. F. Gubkina N. V. Yukhimenko Yu. Yu. Khokhlova I. Yu. Petrakova S. G. Mikhailov CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS Туберкулез и болезни лёгких очаговый туберкулез легких множественная лекарственная устойчивость микобактерий туберкулеза |
| title | CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS |
| title_full | CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS |
| title_fullStr | CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS |
| title_full_unstemmed | CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS |
| title_short | CLINICAL CASES OF FOCAL PULMONARY TUBERCULOSIS IN CHILDREN WITH MINIMUM INVOLVEMENT IN MULTIDRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS |
| title_sort | clinical cases of focal pulmonary tuberculosis in children with minimum involvement in multidrug resistance in mycobacterium tuberculosis |
| topic | очаговый туберкулез легких множественная лекарственная устойчивость микобактерий туберкулеза |
| url | https://www.tibl-journal.com/jour/article/view/353 |
| work_keys_str_mv | AT mfgubkina clinicalcasesoffocalpulmonarytuberculosisinchildrenwithminimuminvolvementinmultidrugresistanceinmycobacteriumtuberculosis AT nvyukhimenko clinicalcasesoffocalpulmonarytuberculosisinchildrenwithminimuminvolvementinmultidrugresistanceinmycobacteriumtuberculosis AT yuyukhokhlova clinicalcasesoffocalpulmonarytuberculosisinchildrenwithminimuminvolvementinmultidrugresistanceinmycobacteriumtuberculosis AT iyupetrakova clinicalcasesoffocalpulmonarytuberculosisinchildrenwithminimuminvolvementinmultidrugresistanceinmycobacteriumtuberculosis AT sgmikhailov clinicalcasesoffocalpulmonarytuberculosisinchildrenwithminimuminvolvementinmultidrugresistanceinmycobacteriumtuberculosis |