Efficiency of photodynamic treatment in patients with early gastric cancer
<p>The experience of photodynamic therapy for early gastric cancer is described in the article. The treatment results in 68 patients who were excluded for convenient surgical treatment because of advanced age or severe co-morbidity are represented. 63 patients had single tumor, 5 patients – 2...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2013-01-01
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| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | http://www.pdt-journal.com:80/jour/article/view/10 |
| _version_ | 1818562073305546752 |
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| author | Е. V. Filonenko V. V. Sokolov Е. S. Karpova |
| author_facet | Е. V. Filonenko V. V. Sokolov Е. S. Karpova |
| author_sort | Е. V. Filonenko |
| collection | DOAJ |
| description | <p>The experience of photodynamic therapy for early gastric cancer is described in the article. The treatment results in 68 patients who were excluded for convenient surgical treatment because of advanced age or severe co-morbidity are represented. 63 patients had single tumor, 5 patients – 2 tumors. Four Russian agents: photogem, photosens, radaсhlorin and alasens, were used for photodynamic therapy. The treatment session was performed under local anesthesia during routine endoscopy with diode laser with wavelength consistent with photosensitizer (photogem – 630 nm, photosens – 670 nm, alasens-induced protoporphyrin IX – 635 nm, radaсhlorin – 662 nm). The short-term results were analyzed 1 month after treatment according to endoscopy, morphological study, CT, ultrasound or endosonography. For 73 lesions complete regression was observed in 53 (72.6%) and partial regression in 20 tumors (27.4%). The efficacy of photodynamic therapy was shown to be directly associated with tumor size. Thus, for tumors up to 1 cm regression occurred in 100% of cases, up to 1.5 cm – in 70.8%, up to 3 cm – in 65.2%, up to 5 cm – in 58.3%. The median survival rates accounted for 7.31 years, 3-year survival – 83±5%, 5-year - 69±8%. The experience showed that the developed method of photodynamic therapy was promising in treatment for early gastric cancer as an alternative to surgery.</p><p> </p> |
| first_indexed | 2024-12-14T00:58:55Z |
| format | Article |
| id | doaj.art-38bd7fa3b1b94a859a8b09798063d04a |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-12-14T00:58:55Z |
| publishDate | 2013-01-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-38bd7fa3b1b94a859a8b09798063d04a2022-12-21T23:23:22ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322013-01-01223710Efficiency of photodynamic treatment in patients with early gastric cancerЕ. V. Filonenko0V. V. Sokolov1Е. S. Karpova2Национальный медицинский исследовательский радиологический центр Минздрава России, Москва, Россия; Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, Россия<p>The experience of photodynamic therapy for early gastric cancer is described in the article. The treatment results in 68 patients who were excluded for convenient surgical treatment because of advanced age or severe co-morbidity are represented. 63 patients had single tumor, 5 patients – 2 tumors. Four Russian agents: photogem, photosens, radaсhlorin and alasens, were used for photodynamic therapy. The treatment session was performed under local anesthesia during routine endoscopy with diode laser with wavelength consistent with photosensitizer (photogem – 630 nm, photosens – 670 nm, alasens-induced protoporphyrin IX – 635 nm, radaсhlorin – 662 nm). The short-term results were analyzed 1 month after treatment according to endoscopy, morphological study, CT, ultrasound or endosonography. For 73 lesions complete regression was observed in 53 (72.6%) and partial regression in 20 tumors (27.4%). The efficacy of photodynamic therapy was shown to be directly associated with tumor size. Thus, for tumors up to 1 cm regression occurred in 100% of cases, up to 1.5 cm – in 70.8%, up to 3 cm – in 65.2%, up to 5 cm – in 58.3%. The median survival rates accounted for 7.31 years, 3-year survival – 83±5%, 5-year - 69±8%. The experience showed that the developed method of photodynamic therapy was promising in treatment for early gastric cancer as an alternative to surgery.</p><p> </p>http://www.pdt-journal.com:80/jour/article/view/10ранний рак желудкафотодинамическая терапияфотогемфотосенсрадахлориналасенс |
| spellingShingle | Е. V. Filonenko V. V. Sokolov Е. S. Karpova Efficiency of photodynamic treatment in patients with early gastric cancer Biomedical Photonics ранний рак желудка фотодинамическая терапия фотогем фотосенс радахлорин аласенс |
| title | Efficiency of photodynamic treatment in patients with early gastric cancer |
| title_full | Efficiency of photodynamic treatment in patients with early gastric cancer |
| title_fullStr | Efficiency of photodynamic treatment in patients with early gastric cancer |
| title_full_unstemmed | Efficiency of photodynamic treatment in patients with early gastric cancer |
| title_short | Efficiency of photodynamic treatment in patients with early gastric cancer |
| title_sort | efficiency of photodynamic treatment in patients with early gastric cancer |
| topic | ранний рак желудка фотодинамическая терапия фотогем фотосенс радахлорин аласенс |
| url | http://www.pdt-journal.com:80/jour/article/view/10 |
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