Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial
Abstract Exercise intolerance is one of the major symptoms of chronic obstructive pulmonary disease (COPD). Exercise training can benefit COPD patients, but the underlying mechanism remains unclear. The modified Total Body Recumbent Stepper (TBRS, Nustep-T4) can benefit patients with stroke, spinal...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15466-2 |
| _version_ | 1811328830592253952 |
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| author | Wentao Duan Dan Zeng Jin Huang Jing Gu San Li Wei Zhou Jinling Ma Yan Jiang Liming Zhu Xudong Xiang Aiguo Dai |
| author_facet | Wentao Duan Dan Zeng Jin Huang Jing Gu San Li Wei Zhou Jinling Ma Yan Jiang Liming Zhu Xudong Xiang Aiguo Dai |
| author_sort | Wentao Duan |
| collection | DOAJ |
| description | Abstract Exercise intolerance is one of the major symptoms of chronic obstructive pulmonary disease (COPD). Exercise training can benefit COPD patients, but the underlying mechanism remains unclear. The modified Total Body Recumbent Stepper (TBRS, Nustep-T4) can benefit patients with stroke, spinal cord injury and amyotrophic lateral sclerosis. Nevertheless, the effect of TBRS training alone on pulmonary rehabilitation (PR) in COPD patients remains largely unknown. We aimed to explore the effect of TBRS training on exercise capacity and the thioredoxin system (TRXS) in COPD patients to provide a novel rehabilitation modality and new theoretical basis for PR of COPD patients. Ninety stable COPD patients were randomly divided into a control group (NC group) and a TBRS training group (TBRS group), with 45 cases in each group. Subjects in the TBRS training group were scheduled to undergo TBRS endurance training triweekly for 12 weeks under the guidance of a rehabilitation therapist. We assessed the primary outcome: exercise capacity (6-min walking distance, 6MWD); and secondary outcomes: perception of dyspnoea (mMRC, Borg), the COPD assessment test (CAT), the BODE index, pulmonary function, the number of acute exacerbations of COPD and oxidative stress (TRXS) at one-year follow-up. Compared with before the intervention and the control group, after the intervention, the TBRS training group, exhibited an increase in the 6MWD (from 366.92 ± 85.81 to 484.10 ± 71.90, 484.10 ± 71.90 vs 370.63 ± 79.87, P < 0.01), while the scores on the BORG, mMRC, BODE index, CAT, and the number of acute exacerbations of COPD were reduced, and the protein and mRNA expression levels of TRXS was significantly increased (P < 0.01). However, no differences were found in PF parameters in the comparison with before the intervention or between groups. TBRS training can effectively increase exercise capacity, while there are indications that it can alleviate COPD-related dyspnoea and reduce the number of acute exacerbations of COPD. Interestingly, long-term regular TBRS training may reduce oxidative stress associated with COPD to increase exercise capacity. |
| first_indexed | 2024-04-13T15:31:56Z |
| format | Article |
| id | doaj.art-38bde1c4a0ca4713be4453ca9f20598c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:31:56Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-38bde1c4a0ca4713be4453ca9f20598c2022-12-22T02:41:21ZengNature PortfolioScientific Reports2045-23222022-07-0112111010.1038/s41598-022-15466-2Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trialWentao Duan0Dan Zeng1Jin Huang2Jing Gu3San Li4Wei Zhou5Jinling Ma6Yan Jiang7Liming Zhu8Xudong Xiang9Aiguo Dai10Department of Respiratory and Critical Care Medicine, Research Unit of Respiratory Diseases, The Second Xiangya Hospital of Central South UniversityInstitute of Respiratory Disease, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Respiratory and Critical Care Medicine, Hunan Provincial People’s Hospital (The First-Affiliated Hospital of Hunan Normal University)Department of Emergency, Institute of Emergency and Difficult Diseases, The Second Xiangya Hospital of Central South UniversityDepartment of Respiratory Diseases, Medical School, Hunan University of Chinese Medicine/Key Laboratory of Vascular Biology and Translational Medicine in Hunan ProvinceAbstract Exercise intolerance is one of the major symptoms of chronic obstructive pulmonary disease (COPD). Exercise training can benefit COPD patients, but the underlying mechanism remains unclear. The modified Total Body Recumbent Stepper (TBRS, Nustep-T4) can benefit patients with stroke, spinal cord injury and amyotrophic lateral sclerosis. Nevertheless, the effect of TBRS training alone on pulmonary rehabilitation (PR) in COPD patients remains largely unknown. We aimed to explore the effect of TBRS training on exercise capacity and the thioredoxin system (TRXS) in COPD patients to provide a novel rehabilitation modality and new theoretical basis for PR of COPD patients. Ninety stable COPD patients were randomly divided into a control group (NC group) and a TBRS training group (TBRS group), with 45 cases in each group. Subjects in the TBRS training group were scheduled to undergo TBRS endurance training triweekly for 12 weeks under the guidance of a rehabilitation therapist. We assessed the primary outcome: exercise capacity (6-min walking distance, 6MWD); and secondary outcomes: perception of dyspnoea (mMRC, Borg), the COPD assessment test (CAT), the BODE index, pulmonary function, the number of acute exacerbations of COPD and oxidative stress (TRXS) at one-year follow-up. Compared with before the intervention and the control group, after the intervention, the TBRS training group, exhibited an increase in the 6MWD (from 366.92 ± 85.81 to 484.10 ± 71.90, 484.10 ± 71.90 vs 370.63 ± 79.87, P < 0.01), while the scores on the BORG, mMRC, BODE index, CAT, and the number of acute exacerbations of COPD were reduced, and the protein and mRNA expression levels of TRXS was significantly increased (P < 0.01). However, no differences were found in PF parameters in the comparison with before the intervention or between groups. TBRS training can effectively increase exercise capacity, while there are indications that it can alleviate COPD-related dyspnoea and reduce the number of acute exacerbations of COPD. Interestingly, long-term regular TBRS training may reduce oxidative stress associated with COPD to increase exercise capacity.https://doi.org/10.1038/s41598-022-15466-2 |
| spellingShingle | Wentao Duan Dan Zeng Jin Huang Jing Gu San Li Wei Zhou Jinling Ma Yan Jiang Liming Zhu Xudong Xiang Aiguo Dai Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial Scientific Reports |
| title | Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial |
| title_full | Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial |
| title_fullStr | Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial |
| title_full_unstemmed | Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial |
| title_short | Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial |
| title_sort | effect of modified total body recumbent stepper training on exercise capacity and thioredoxin in copd a randomized clinical trial |
| url | https://doi.org/10.1038/s41598-022-15466-2 |
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