LTX-315 triggers anticancer immunity by inducing MyD88-dependent maturation of dendritic cells

LTX-315 triggers anticancer immunity by inducing MyD88-dependent maturation of dendritic cells

LTX-315 is a synthetic cationic oncolytic peptide with potent anticancer activity but limited toxicity for non-malignant cells. LTX-315 induces both immunogenic tumor cell death and generation of tumor-specific immune responses in multiple experimental tumor models. Given the central role of dendrit...

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Bibliographic Details
Main Authors: Xiao-Qing Li, Takahiro Yamazaki, Tianzhen He, Md Masud Alam, Jia Liu, Anna L. Trivett, Baldur Sveinbjørnsson, Øystein Rekdal, Lorenzo Galluzzi, Joost J. Oppenheim, De Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
antitumor immunity
dendritic cells
LTX-315
toll-like receptors
MyD88
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332922/full

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