An analytical “quality by design” approach in RP-HPLC method development and validation for reliable and rapid estimation of irinotecan in an injectable formulation

An analytical “quality by design” approach in RP-HPLC method development and validation for reliable and rapid estimation of irinotecan in an injectable formulation

The objective of the present study was to develop a robust, simple, economical and sensitive HPLC-UV method using the “quality-by-design” approach for the estimation of irinotecan (IRI) in marketed formulations. RP-HPLC method was developed by applying Box-Behnken design with Hyper-Clone (Phenomenex...

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Bibliographic Details
Main Authors: Bhaskaran Navya Ajitkumar, Kumar Lalit, Reddy M Sreenivasa, Pai Girish K
Format: Article
Language:English
Published: Sciendo 2021-03-01
Series:Acta Pharmaceutica
Subjects:
irinotecan
hplc-uv
“quality by design”
full factorial design
box-behnken design
Online Access:https://doi.org/10.2478/acph-2021-0008

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