Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy
Objective: The aim of the current study was to investigate the alterations in the neural networks of patients with temporal lobe epilepsy (TLE) during working memory (WM) encoding.Methods: Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.770678/full |
| _version_ | 1818284607993282560 |
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| author | Liping Pan Yakun Wu Yakun Wu Jie Bao Dandan Guo Xin Zhang Jiajing Wang Meili Deng Peiran Yu Gaoxu Wei Lulin Zhang Lulin Zhang Xiao Qin Yijun Song Yijun Song |
| author_facet | Liping Pan Yakun Wu Yakun Wu Jie Bao Dandan Guo Xin Zhang Jiajing Wang Meili Deng Peiran Yu Gaoxu Wei Lulin Zhang Lulin Zhang Xiao Qin Yijun Song Yijun Song |
| author_sort | Liping Pan |
| collection | DOAJ |
| description | Objective: The aim of the current study was to investigate the alterations in the neural networks of patients with temporal lobe epilepsy (TLE) during working memory (WM) encoding.Methods: Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electroencephalogram signals were recorded. The neural networks during WM encoding were calculated in TLE patients with (TLE-WM) and without (TLE-N) WM deficits.Results: Functional connectivity strength decreased, and the theta network was altered in the TLE-WM group, although no significant differences in clinical features were observed between the TLE-N and TLE-WM groups.Conclusions: Not all patients with TLE present with cognitive impairments and alterations in the theta network were identified in TLE patients with functional cognitive deficits.Significance: The theta network may represent a sensitive measure of cognitive impairment and could predict cognitive outcomes among patients with TLE. |
| first_indexed | 2024-12-13T00:55:30Z |
| format | Article |
| id | doaj.art-38bf269ef1aa40ee983f26e210c8ff8d |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T00:55:30Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-38bf269ef1aa40ee983f26e210c8ff8d2022-12-22T00:04:48ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-01-011510.3389/fnhum.2021.770678770678Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe EpilepsyLiping Pan0Yakun Wu1Yakun Wu2Jie Bao3Dandan Guo4Xin Zhang5Jiajing Wang6Meili Deng7Peiran Yu8Gaoxu Wei9Lulin Zhang10Lulin Zhang11Xiao Qin12Yijun Song13Yijun Song14General Medicine Department, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tangshan Gongren Hospital, Tangshan, ChinaDepartment of Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaSchool of Basic Medical Science, Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaGeneral Medicine Department, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Central Nerve Injury Repair and Regeneration, Ministry of Education, Tianjin Neurological Institute, Tianjin, ChinaObjective: The aim of the current study was to investigate the alterations in the neural networks of patients with temporal lobe epilepsy (TLE) during working memory (WM) encoding.Methods: Patients with TLE (n = 52) and healthy volunteers (n = 35) completed a WM task, during which 34-channel electroencephalogram signals were recorded. The neural networks during WM encoding were calculated in TLE patients with (TLE-WM) and without (TLE-N) WM deficits.Results: Functional connectivity strength decreased, and the theta network was altered in the TLE-WM group, although no significant differences in clinical features were observed between the TLE-N and TLE-WM groups.Conclusions: Not all patients with TLE present with cognitive impairments and alterations in the theta network were identified in TLE patients with functional cognitive deficits.Significance: The theta network may represent a sensitive measure of cognitive impairment and could predict cognitive outcomes among patients with TLE.https://www.frontiersin.org/articles/10.3389/fnhum.2021.770678/fullworking memoryencodingtemporal lobe epilepsythetaneural network |
| spellingShingle | Liping Pan Yakun Wu Yakun Wu Jie Bao Dandan Guo Xin Zhang Jiajing Wang Meili Deng Peiran Yu Gaoxu Wei Lulin Zhang Lulin Zhang Xiao Qin Yijun Song Yijun Song Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy Frontiers in Human Neuroscience working memory encoding temporal lobe epilepsy theta neural network |
| title | Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy |
| title_full | Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy |
| title_fullStr | Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy |
| title_full_unstemmed | Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy |
| title_short | Alterations in Neural Networks During Working Memory Encoding Related to Cognitive Impairment in Temporal Lobe Epilepsy |
| title_sort | alterations in neural networks during working memory encoding related to cognitive impairment in temporal lobe epilepsy |
| topic | working memory encoding temporal lobe epilepsy theta neural network |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.770678/full |
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