Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study
Non-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation....
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.723837/full |
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| author | Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo |
| author_facet | Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo |
| author_sort | Ying Zhang |
| collection | DOAJ |
| description | Non-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation. Echocardiogram allows non-invasive assessment of systemic circulation, which may provide an effective supplement to RRI. To find the value of RRI combined with echocardiographic parameters in the non-invasive early prediction of S-AKI, we designed this experiment with repeated measurements of ultrasonographic parameters in the early stage of sepsis (3, 6, 12, and 24 h) in cecum ligation and puncture (CLP) rats (divided into AKI and non-AKI groups at 24 h based on serum creatinine), with sham-operated group serving as controls. Our results found that RRI alone could not effectively predict S-AKI, but when combined with echocardiographic parameters (heart rate, left ventricular end-diastolic internal diameter, and left ventricular end-systolic internal diameter), the predictive value was significantly improved, especially in the early stage of sepsis (3 h, AUC: 0.948, 95% CI 0.839–0.992, P < 0.001), and far earlier than the conventional renal function indicators (serum creatinine and blood urea nitrogen), which only significantly elevated at 24 h. Our method showed novel advances and potential in the early detection of S-AKI. |
| first_indexed | 2024-12-17T12:52:08Z |
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| id | doaj.art-38c2c36affb94a6b8cc8d547643776c7 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-17T12:52:08Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-38c2c36affb94a6b8cc8d547643776c72022-12-21T21:47:35ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-12-01810.3389/fmed.2021.723837723837Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental StudyYing Zhang0Ying Zhang1Jianing Zhu2Jianing Zhu3Chuyue Zhang4Chuyue Zhang5Jing Xiao6Jing Xiao7Chao Liu8Chao Liu9Chao Liu10Shuo Wang11Shuo Wang12Ping Zhao13Ping Zhao14Yaqiong Zhu15Li Wang16Qiuyang Li17Yukun Luo18Yukun Luo19School of Medicine, Nankai University, Tianjin, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaMedical School of Chinese People's Liberation Army (PLA), Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Nephrology, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaMedical School of Chinese People's Liberation Army (PLA), Beijing, ChinaDepartment of Nephrology, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Critical Care Medicine, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaMedical School of Chinese People's Liberation Army (PLA), Beijing, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaMedical School of Chinese People's Liberation Army (PLA), Beijing, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Critical Care Medicine, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Ultrasound, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaNon-invasive early prediction of septic acute kidney injury (S-AKI) is still urgent and challenging. Increased Doppler-based renal resistive index (RRI) has been shown to be associated with S-AKI, but its clinical use is limited, which may be explained by the complex effects of systemic circulation. Echocardiogram allows non-invasive assessment of systemic circulation, which may provide an effective supplement to RRI. To find the value of RRI combined with echocardiographic parameters in the non-invasive early prediction of S-AKI, we designed this experiment with repeated measurements of ultrasonographic parameters in the early stage of sepsis (3, 6, 12, and 24 h) in cecum ligation and puncture (CLP) rats (divided into AKI and non-AKI groups at 24 h based on serum creatinine), with sham-operated group serving as controls. Our results found that RRI alone could not effectively predict S-AKI, but when combined with echocardiographic parameters (heart rate, left ventricular end-diastolic internal diameter, and left ventricular end-systolic internal diameter), the predictive value was significantly improved, especially in the early stage of sepsis (3 h, AUC: 0.948, 95% CI 0.839–0.992, P < 0.001), and far earlier than the conventional renal function indicators (serum creatinine and blood urea nitrogen), which only significantly elevated at 24 h. Our method showed novel advances and potential in the early detection of S-AKI.https://www.frontiersin.org/articles/10.3389/fmed.2021.723837/fullsepsisacute kidney injuryrenal resistive indexechocardiogramultrasonography |
| spellingShingle | Ying Zhang Ying Zhang Jianing Zhu Jianing Zhu Chuyue Zhang Chuyue Zhang Jing Xiao Jing Xiao Chao Liu Chao Liu Chao Liu Shuo Wang Shuo Wang Ping Zhao Ping Zhao Yaqiong Zhu Li Wang Qiuyang Li Yukun Luo Yukun Luo Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study Frontiers in Medicine sepsis acute kidney injury renal resistive index echocardiogram ultrasonography |
| title | Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_full | Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_fullStr | Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_full_unstemmed | Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_short | Non-invasive Early Prediction of Septic Acute Kidney Injury by Doppler-Based Renal Resistive Indexes Combined With Echocardiographic Parameters: An Experimental Study |
| title_sort | non invasive early prediction of septic acute kidney injury by doppler based renal resistive indexes combined with echocardiographic parameters an experimental study |
| topic | sepsis acute kidney injury renal resistive index echocardiogram ultrasonography |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.723837/full |
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