VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS
Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disorder characterized by an immune response targeting the thyroid gland. Genetic factors play a significant role in AIT susceptibility, with immune-related genes, especially the vitamin D receptor (VDR) gene, potentially influencing AIT develop...
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2023-12-01
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| Series: | Sanamed |
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| Online Access: | https://new.sanamed.rs/vitamin-d-levels-and-vdr/ |
| _version_ | 1797225335335419904 |
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| author | Shaikh Parveen Aleena Shaikh Parveen Nameera Nakashidze Irina |
| author_facet | Shaikh Parveen Aleena Shaikh Parveen Nameera Nakashidze Irina |
| author_sort | Shaikh Parveen Aleena |
| collection | DOAJ |
| description | Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disorder characterized by an immune response targeting the thyroid gland. Genetic factors play a significant role in AIT susceptibility, with immune-related genes, especially the vitamin D receptor (VDR) gene, potentially influencing AIT development. This comprehensive review delves into the intricate association between VDR gene polymorphisms, particularly rs2228570 (FokI), and AIT susceptibility, exploring various populations. Research has unveiled contrasting outcomes regarding the link between the VDR rs2228570 polymorphism and AIT risk across diverse ethnic groups. Certain populations have exhibited a noteworthy correlation, suggesting that population-specific genetic factors contribute to AIT risk. A recurring observation of vitamin D deficiency in AIT patients has correlated with elevated anti-thyroid antibodies, abnormal thyroid function, and thyroid volume. The results emphasize the possible role of vitamin D in the development of AIT, suggesting the importance of vitamin D supplementation to address deficiencies associated with AIT. In addition to VDR rs2228570, other genetic variants have also shown associations with AIT susceptibility, displaying varying results across different populations. Ethnicity emerges as a pivotal factor influencing these associations, underscoring the need to consider genetic variations in diverse populations. We emphasize the intricate interplay between VDR gene polymorphisms, vitamin D, and AIT susceptibility. Extensive research is essential to unveil the clinical significance of these genetic variations, offering prospects for enhanced diagnostic and therapeutic strategies for individuals with AIT. |
| first_indexed | 2024-03-08T10:18:33Z |
| format | Article |
| id | doaj.art-38c3b624ff4349eca48bb292bc1c3fc2 |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-04-24T14:07:23Z |
| publishDate | 2023-12-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-38c3b624ff4349eca48bb292bc1c3fc22024-04-03T10:03:11ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712023-12-0118321722210.5937/sanamed0-46407VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITISShaikh Parveen Aleena0 Shaikh Parveen Nameera1Nakashidze Irina2Batumi Shota Rustaveli State University, Batumi, GeorgiaBatumi Shota Rustaveli State University, Batumi, GeorgiaBatumi Shota Rustaveli State University, Batumi, GeorgiaAutoimmune Thyroiditis (AIT) is a prevalent autoimmune disorder characterized by an immune response targeting the thyroid gland. Genetic factors play a significant role in AIT susceptibility, with immune-related genes, especially the vitamin D receptor (VDR) gene, potentially influencing AIT development. This comprehensive review delves into the intricate association between VDR gene polymorphisms, particularly rs2228570 (FokI), and AIT susceptibility, exploring various populations. Research has unveiled contrasting outcomes regarding the link between the VDR rs2228570 polymorphism and AIT risk across diverse ethnic groups. Certain populations have exhibited a noteworthy correlation, suggesting that population-specific genetic factors contribute to AIT risk. A recurring observation of vitamin D deficiency in AIT patients has correlated with elevated anti-thyroid antibodies, abnormal thyroid function, and thyroid volume. The results emphasize the possible role of vitamin D in the development of AIT, suggesting the importance of vitamin D supplementation to address deficiencies associated with AIT. In addition to VDR rs2228570, other genetic variants have also shown associations with AIT susceptibility, displaying varying results across different populations. Ethnicity emerges as a pivotal factor influencing these associations, underscoring the need to consider genetic variations in diverse populations. We emphasize the intricate interplay between VDR gene polymorphisms, vitamin D, and AIT susceptibility. Extensive research is essential to unveil the clinical significance of these genetic variations, offering prospects for enhanced diagnostic and therapeutic strategies for individuals with AIT.https://new.sanamed.rs/vitamin-d-levels-and-vdr/vdr genesnpvitamin dautoimmune thyroiditis |
| spellingShingle | Shaikh Parveen Aleena Shaikh Parveen Nameera Nakashidze Irina VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS Sanamed vdr gene snp vitamin d autoimmune thyroiditis |
| title | VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS |
| title_full | VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS |
| title_fullStr | VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS |
| title_full_unstemmed | VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS |
| title_short | VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS |
| title_sort | vitamin d levels and vdr rs2228570 genetic variant in autoimmune thyroiditis |
| topic | vdr gene snp vitamin d autoimmune thyroiditis |
| url | https://new.sanamed.rs/vitamin-d-levels-and-vdr/ |
| work_keys_str_mv | AT shaikhparveenaleena vitamindlevelsandvdrrs2228570geneticvariantinautoimmunethyroiditis AT shaikhparveennameera vitamindlevelsandvdrrs2228570geneticvariantinautoimmunethyroiditis AT nakashidzeirina vitamindlevelsandvdrrs2228570geneticvariantinautoimmunethyroiditis |