The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech
The article presents a case report, and a literature review on benign epileptiform discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population. Examinin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-04-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/773 |
| _version_ | 1797879362308014080 |
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| author | E. A. Morozova M. V. Belousova D. V. Morozov M. A. Utkuzova |
| author_facet | E. A. Morozova M. V. Belousova D. V. Morozov M. A. Utkuzova |
| author_sort | E. A. Morozova |
| collection | DOAJ |
| description | The article presents a case report, and a literature review on benign epileptiform discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population. Examining children with autistic spectrum disorder, BEDC is revealed in 20% cases, whereas in those with attention deficit and hyperactivity disorder (ADHD) or speech disorder – in 25% and 18% cases, respectively. Many studies considering BEDC as a genetic marker of brain immaturity highlighted by different level of expressiveness and penetrance are discussed. It is highly probable that cognitive and speech disorders as well as ADHD in children with BEDC may be genetically determined. However, pediatric BEDC may be asymptomatic or become manifested by diverse psychoneurological symptoms accounted for by developed epileptic encephalopathy and continuous spike and waves during slow wave sleep (CSWS) requiring specialized long-term treatment. Markedly elevated CSWS with morphological BEDC affects interneuron connections, which, in turn, alters memory consolidation in mesial temporal regions. The literature analysis revealed that children with BEDC-like epileptic activity require obligatory periodic sleep electroencephalographic control and dynamic neuropsychological evaluation due to high incidence of speech, mnestic and behavioral disorders. Seizure-free BEDC-like epileptic activity should be corrected pharmaceutically only in case of established causative link with progressive cognitive impairments. |
| first_indexed | 2024-04-10T02:46:33Z |
| format | Article |
| id | doaj.art-38c4b641343e45e48a1cd22193fd3fe7 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:46:33Z |
| publishDate | 2022-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-38c4b641343e45e48a1cd22193fd3fe72023-03-13T07:44:18ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882022-04-01141374710.17749/2077-8333/epi.par.con.2022.109570The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speechE. A. Morozova0M. V. Belousova1D. V. Morozov2M. A. Utkuzova3Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional EducationKazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional EducationKazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional EducationKazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional EducationThe article presents a case report, and a literature review on benign epileptiform discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population. Examining children with autistic spectrum disorder, BEDC is revealed in 20% cases, whereas in those with attention deficit and hyperactivity disorder (ADHD) or speech disorder – in 25% and 18% cases, respectively. Many studies considering BEDC as a genetic marker of brain immaturity highlighted by different level of expressiveness and penetrance are discussed. It is highly probable that cognitive and speech disorders as well as ADHD in children with BEDC may be genetically determined. However, pediatric BEDC may be asymptomatic or become manifested by diverse psychoneurological symptoms accounted for by developed epileptic encephalopathy and continuous spike and waves during slow wave sleep (CSWS) requiring specialized long-term treatment. Markedly elevated CSWS with morphological BEDC affects interneuron connections, which, in turn, alters memory consolidation in mesial temporal regions. The literature analysis revealed that children with BEDC-like epileptic activity require obligatory periodic sleep electroencephalographic control and dynamic neuropsychological evaluation due to high incidence of speech, mnestic and behavioral disorders. Seizure-free BEDC-like epileptic activity should be corrected pharmaceutically only in case of established causative link with progressive cognitive impairments.https://www.epilepsia.su/jour/article/view/773benign epileptiform discharges of childhoodbedccognitive impairmentattention deficit and hyperactivity disorderadhdspeech disordersautistic spectrum disordersasdepileptic encephalopathyhereditary impairment of brain maturation |
| spellingShingle | E. A. Morozova M. V. Belousova D. V. Morozov M. A. Utkuzova The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech Эпилепсия и пароксизмальные состояния benign epileptiform discharges of childhood bedc cognitive impairment attention deficit and hyperactivity disorder adhd speech disorders autistic spectrum disorders asd epileptic encephalopathy hereditary impairment of brain maturation |
| title | The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech |
| title_full | The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech |
| title_fullStr | The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech |
| title_full_unstemmed | The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech |
| title_short | The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech |
| title_sort | effect of benign epileptiform discharges of childhood on cognitive function behavior and speech |
| topic | benign epileptiform discharges of childhood bedc cognitive impairment attention deficit and hyperactivity disorder adhd speech disorders autistic spectrum disorders asd epileptic encephalopathy hereditary impairment of brain maturation |
| url | https://www.epilepsia.su/jour/article/view/773 |
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