Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study
<h4>Objectives</h4> Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212190/?tool=EBI |
| _version_ | 1797818268279373824 |
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| author | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen |
| author_facet | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen |
| author_sort | Amir Avnit |
| collection | DOAJ |
| description | <h4>Objectives</h4> Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity. <h4>Methods</h4> We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propagation (ISP), which is reversely indicative of interhemispheric connectivity. <h4>Results</h4> Compared to controls, the ADHD group demonstrated elongated SSRT, reduced N200 right-frontal-asymmetry, weaker TEP, and stronger ISP. Moreover, in the ADHD group, N200 right-frontal-asymmetry correlated with SSRT, with TEP, and with symptoms severity. Conversely, no relationship was observed between ISP and N200 right-frontal-asymmetry, and both TEP and ISP were found to be unrelated to SSRT. <h4>Conclusions</h4> Our results indicate that abnormal frontal asymmetry is related to a key cognitive symptom in ADHD and suggest that it is underlined by reduced right-frontal excitability. |
| first_indexed | 2024-03-13T09:05:34Z |
| format | Article |
| id | doaj.art-38c4e96552af4f9ca332997b80b4061b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T09:05:34Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-38c4e96552af4f9ca332997b80b4061b2023-05-28T05:31:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG studyAmir AvnitSamuel ZibmanUri AlyagonAbraham Zangen<h4>Objectives</h4> Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity. <h4>Methods</h4> We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propagation (ISP), which is reversely indicative of interhemispheric connectivity. <h4>Results</h4> Compared to controls, the ADHD group demonstrated elongated SSRT, reduced N200 right-frontal-asymmetry, weaker TEP, and stronger ISP. Moreover, in the ADHD group, N200 right-frontal-asymmetry correlated with SSRT, with TEP, and with symptoms severity. Conversely, no relationship was observed between ISP and N200 right-frontal-asymmetry, and both TEP and ISP were found to be unrelated to SSRT. <h4>Conclusions</h4> Our results indicate that abnormal frontal asymmetry is related to a key cognitive symptom in ADHD and suggest that it is underlined by reduced right-frontal excitability.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212190/?tool=EBI |
| spellingShingle | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study PLoS ONE |
| title | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study |
| title_full | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study |
| title_fullStr | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study |
| title_full_unstemmed | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study |
| title_short | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study |
| title_sort | abnormal functional asymmetry and its behavioural correlates in adults with adhd a tms eeg study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212190/?tool=EBI |
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