Heart failure induced by perinatal ablation of cardiac myosin light chain kinase

Heart failure induced by perinatal ablation of cardiac myosin light chain kinase

Background: Germline knockout mice are invaluable in understanding the function of the targeted genes. Sometimes, however, unexpected phenotypes are encountered, due in part to the activation of compensatory mechanisms. Germline ablation of cardiac myosin light chain kinase (cMLCK) causes mild cardi...

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Bibliographic Details
Main Authors: Yasmin F. K. Islam, Ryan Joseph, Rajib Chowdhury, Robert Henry Anderson, Hideko Kasahara
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Physiology
Subjects:
Heart Failure
kinase
perinatal
knockout
Myosin light chain kinase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00480/full

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