Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children
Introduction: Nonalcoholic Fatty Liver Disease (NAFLD) is characterised by fat accumulation in the liver. Treatment of NAFLD in children is an important issue but the options are limited. Green tea has antioxidant and anti-hyperlipidemic effects but studies; on the effect of green tea in children ar...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2019-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12986/35236_CE[Ra1]_F(SL)_PF1(AJ_SHU)_PN(SL).pdf |
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| author | Noushin Rostampour Karam Ali Kasiri Elham Hashemi-Dehkordi Abdol Majid Taheri Anahita Farahzad Broujeni Mahmoud Rafieian-Kopaei |
| author_facet | Noushin Rostampour Karam Ali Kasiri Elham Hashemi-Dehkordi Abdol Majid Taheri Anahita Farahzad Broujeni Mahmoud Rafieian-Kopaei |
| author_sort | Noushin Rostampour |
| collection | DOAJ |
| description | Introduction: Nonalcoholic Fatty Liver Disease (NAFLD) is characterised by fat accumulation in the liver. Treatment of NAFLD in children is an important issue but the options are limited. Green tea has antioxidant and anti-hyperlipidemic effects but studies; on the effect of green tea in children are limited. Aim: To investigate effect of green tea on NAFLD in children. Materials and Methods: In this study, 52 children aged 10-16 years with NAFLD were divided into two groups of 26 each: Intervention and control. For both groups, modification of diet and intensification of physical activity were prescribed for three months. Intervention group was also treated with green tea tablets. Sonography and measurements of liver enzymes {Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST)}, lipid profile and Body Mass Index (BMI) were conducted before and after the intervention. The data were analysed by the Statistical Package for the Social Sciences (SPSS) version 19.0 using ANCOVA. Results: After treatment with green tea, fatty liver grade decreased significantly in the intervention group compared to control group (p<0.0001). In addition, this treatment caused significant decrease in ALT, AST, and triglyceride levels and significant increase in High-Density Lipoprotein (HDL) level (p<0.05), but Low-Density Lipoprotein (LDL) level did not decrease significantly in the intervention group compared to control. Conclusion: Oral prescription of green tea was effective in improving fatty liver grade, decreasing hepatic fat accumulation and improving liver function, weight loss and reducing ALT and AST without any side effects. These effects can be due to green tea compounds such as polyphenols especially catechin and antioxidant and anti-hyperlipidemic effects. |
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| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T05:32:07Z |
| publishDate | 2019-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-38c864576fb946b29f287ebc9e6f60f32022-12-21T19:51:42ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-07-01137BC04BC0710.7860/JCDR/2019/35236.12986Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old ChildrenNoushin Rostampour0Karam Ali Kasiri1Elham Hashemi-Dehkordi2Abdol Majid Taheri3Anahita Farahzad Broujeni4Mahmoud Rafieian-Kopaei5Assistant Professor, Department of Paediatric Endocrinology, Shahrekord University of Medical Sciences, Shahrekord, Iran; Assistant Professor, Department of Paediatric Endocrinology, Isfahan University of Medical Sciences, Isfahan, Iran.Associate Professor, Department of Paediatric Gastroentrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.Assistant Professor, Department of Paediatric Endocrinology, Shahrekord University of Medical Sciences, Shahrekord, Iran; Assistant Professor, Department of Paediatric Endocrinology, Child Growth and Development Research Centre, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan, Iran.Assistant Professor, Department of Radiology, Shahrekord University of Medical Sciences, Shahrekord, Iran.Assistant Professor, Department of Paediatric, Shahrekord University of Medical Sciences, Shahrekord, Iran.Professor, Medical Plant Research Centre, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.Introduction: Nonalcoholic Fatty Liver Disease (NAFLD) is characterised by fat accumulation in the liver. Treatment of NAFLD in children is an important issue but the options are limited. Green tea has antioxidant and anti-hyperlipidemic effects but studies; on the effect of green tea in children are limited. Aim: To investigate effect of green tea on NAFLD in children. Materials and Methods: In this study, 52 children aged 10-16 years with NAFLD were divided into two groups of 26 each: Intervention and control. For both groups, modification of diet and intensification of physical activity were prescribed for three months. Intervention group was also treated with green tea tablets. Sonography and measurements of liver enzymes {Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST)}, lipid profile and Body Mass Index (BMI) were conducted before and after the intervention. The data were analysed by the Statistical Package for the Social Sciences (SPSS) version 19.0 using ANCOVA. Results: After treatment with green tea, fatty liver grade decreased significantly in the intervention group compared to control group (p<0.0001). In addition, this treatment caused significant decrease in ALT, AST, and triglyceride levels and significant increase in High-Density Lipoprotein (HDL) level (p<0.05), but Low-Density Lipoprotein (LDL) level did not decrease significantly in the intervention group compared to control. Conclusion: Oral prescription of green tea was effective in improving fatty liver grade, decreasing hepatic fat accumulation and improving liver function, weight loss and reducing ALT and AST without any side effects. These effects can be due to green tea compounds such as polyphenols especially catechin and antioxidant and anti-hyperlipidemic effects.https://jcdr.net/articles/PDF/12986/35236_CE[Ra1]_F(SL)_PF1(AJ_SHU)_PN(SL).pdfalanine aminotransferaseaspartate aminotransferasegreen tea extractnonalcoholic steatohepatitis |
| spellingShingle | Noushin Rostampour Karam Ali Kasiri Elham Hashemi-Dehkordi Abdol Majid Taheri Anahita Farahzad Broujeni Mahmoud Rafieian-Kopaei Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children Journal of Clinical and Diagnostic Research alanine aminotransferase aspartate aminotransferase green tea extract nonalcoholic steatohepatitis |
| title | Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children |
| title_full | Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children |
| title_fullStr | Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children |
| title_full_unstemmed | Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children |
| title_short | Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children |
| title_sort | therapeutic effects of green tea on nonalcoholic fatty liver disease in 10 16 year old children |
| topic | alanine aminotransferase aspartate aminotransferase green tea extract nonalcoholic steatohepatitis |
| url | https://jcdr.net/articles/PDF/12986/35236_CE[Ra1]_F(SL)_PF1(AJ_SHU)_PN(SL).pdf |
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