Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma

Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma

Abstract Background Snail, a transcriptional factor and repressor of E‐cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and in epithelial cells. Snail also mediates tumor progression and metastases. Sile...

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Bibliographic Details
Main Authors: Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O'Shea, Ronald J Neufeld, Myron R Szewczuk
Format: Article
Language:English
Published: Wiley 2014-12-01
Series:Clinical and Translational Medicine
Subjects:
Human ovarian cancer
Tumor neovascularization
Silencing transcriptional repressors Snail and Slug
Oseltamivir phosphate
Online Access:https://doi.org/10.1186/s40169-014-0028-z

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