Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity
Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/07467 |
| _version_ | 1828374980012802048 |
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| author | Meghan O Altman Jack R Bennink Jonathan W Yewdell Brantley R Herrin |
| author_facet | Meghan O Altman Jack R Bennink Jonathan W Yewdell Brantley R Herrin |
| author_sort | Meghan O Altman |
| collection | DOAJ |
| description | Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies (Abs) to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ∼80% of the response on hemagglutinin (HA), mainly through recognition of the major antigenic sites in the HA globular head domain. Our findings predict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal models for understanding human Ab responses to viruses and protein immunogens. |
| first_indexed | 2024-04-14T07:40:18Z |
| format | Article |
| id | doaj.art-38c995b59f6e4f42b6a5fe63c1b0968f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:40:18Z |
| publishDate | 2015-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-38c995b59f6e4f42b6a5fe63c1b0968f2022-12-22T02:05:30ZengeLife Sciences Publications LtdeLife2050-084X2015-08-01410.7554/eLife.07467Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicityMeghan O Altman0Jack R Bennink1Jonathan W Yewdell2Brantley R Herrin3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United StatesLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United StatesLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United StatesDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, United StatesImmunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies (Abs) to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ∼80% of the response on hemagglutinin (HA), mainly through recognition of the major antigenic sites in the HA globular head domain. Our findings predict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal models for understanding human Ab responses to viruses and protein immunogens.https://elifesciences.org/articles/07467lampreyimmunodominanceantibodiesantigenicityinfluenzahemagglutinin |
| spellingShingle | Meghan O Altman Jack R Bennink Jonathan W Yewdell Brantley R Herrin Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity eLife lamprey immunodominance antibodies antigenicity influenza hemagglutinin |
| title | Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity |
| title_full | Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity |
| title_fullStr | Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity |
| title_full_unstemmed | Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity |
| title_short | Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity |
| title_sort | lamprey vlrb response to influenza virus supports universal rules of immunogenicity and antigenicity |
| topic | lamprey immunodominance antibodies antigenicity influenza hemagglutinin |
| url | https://elifesciences.org/articles/07467 |
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