Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping
Abstract Background To investigate the biochemical changes in lumbar facet joint (LFJ) and intervertebral disc (IVD) with different degenerative grade by T2* mapping. Methods Sixty-eight patients with low back pain (study group) and 20 volunteers (control group) underwent standard MRI protocols and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-024-07265-9 |
| _version_ | 1797247527850868736 |
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| author | Yi Ding Liping Liu Jiangyou Shi Xiaodong Zhang Rongchun Chen Shuaishuai Xu |
| author_facet | Yi Ding Liping Liu Jiangyou Shi Xiaodong Zhang Rongchun Chen Shuaishuai Xu |
| author_sort | Yi Ding |
| collection | DOAJ |
| description | Abstract Background To investigate the biochemical changes in lumbar facet joint (LFJ) and intervertebral disc (IVD) with different degenerative grade by T2* mapping. Methods Sixty-eight patients with low back pain (study group) and 20 volunteers (control group) underwent standard MRI protocols and axial T2* mapping. Morphological evaluation of LFJ and IVD were performed on T2-weighted imaging according to Weishaupt and Pfirrmann grading system, respectively. T2* values of LFJ and of AF (anterior annulus fibrosus), NP (nucleus pulposus), and PF (posterior annulus fibrosus) in IVD were measured. Kruskal-Wallis test and Wilcoxon rank-sum test were used to compare T2* values of subjects with different degenerative grade. Results The mean T2* value of grade 0 LFJ (21.68[17.77,26.13]) was higher than those of grade I (18.42[15.68,21.8], p < 0.001), grade II (18.98[15.56,22.76], p = 0.011) and grade III (18.38[16.05,25.07], p = 0.575) LFJ in study group, and a moderate correlation was observed between T2* value and LFJ grade (rho=-0.304, p < 0.001) in control group. In the analysis of IVD, a moderate correlation was observed between AF T2* value and IVD grade (rho=-0.323, p < 0.001), and between NP T2* value and IVD grade (rho=-0.328, p < 0.001), while no significant difference was observed between the T2* values of PF in IVD of different grade in study group. Conclusions Downward trend of T2* values can be found in LFJ, AF and NP as the degenerative grade rised. But in elderly patients with low back pain, no change trend was found in LFJ due to increased fluid accumulation in the joint space. |
| first_indexed | 2024-04-24T20:00:07Z |
| format | Article |
| id | doaj.art-38ca7ba7f22f4a10bc3fcaea1b4fca11 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-24T20:00:07Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-38ca7ba7f22f4a10bc3fcaea1b4fca112024-03-24T12:08:15ZengBMCBMC Musculoskeletal Disorders1471-24742024-03-012511710.1186/s12891-024-07265-9Biochemical changes in lumbar facet joint and disc degeneration by T2* mappingYi Ding0Liping Liu1Jiangyou Shi2Xiaodong Zhang3Rongchun Chen4Shuaishuai Xu5Department of Spine Surgery, Ganzhou People’s HospitalDepartment of Spine Surgery, Ganzhou People’s HospitalDepartment of Spine Surgery, Ganzhou People’s HospitalDepartment of Medical Imaging, Ganzhou People’s HospitalDepartment of Spine Surgery, Ganzhou People’s HospitalDepartment of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Background To investigate the biochemical changes in lumbar facet joint (LFJ) and intervertebral disc (IVD) with different degenerative grade by T2* mapping. Methods Sixty-eight patients with low back pain (study group) and 20 volunteers (control group) underwent standard MRI protocols and axial T2* mapping. Morphological evaluation of LFJ and IVD were performed on T2-weighted imaging according to Weishaupt and Pfirrmann grading system, respectively. T2* values of LFJ and of AF (anterior annulus fibrosus), NP (nucleus pulposus), and PF (posterior annulus fibrosus) in IVD were measured. Kruskal-Wallis test and Wilcoxon rank-sum test were used to compare T2* values of subjects with different degenerative grade. Results The mean T2* value of grade 0 LFJ (21.68[17.77,26.13]) was higher than those of grade I (18.42[15.68,21.8], p < 0.001), grade II (18.98[15.56,22.76], p = 0.011) and grade III (18.38[16.05,25.07], p = 0.575) LFJ in study group, and a moderate correlation was observed between T2* value and LFJ grade (rho=-0.304, p < 0.001) in control group. In the analysis of IVD, a moderate correlation was observed between AF T2* value and IVD grade (rho=-0.323, p < 0.001), and between NP T2* value and IVD grade (rho=-0.328, p < 0.001), while no significant difference was observed between the T2* values of PF in IVD of different grade in study group. Conclusions Downward trend of T2* values can be found in LFJ, AF and NP as the degenerative grade rised. But in elderly patients with low back pain, no change trend was found in LFJ due to increased fluid accumulation in the joint space.https://doi.org/10.1186/s12891-024-07265-9Magnetic resonance imagingT2* mappingLumbar facet jointIntervertebral disc |
| spellingShingle | Yi Ding Liping Liu Jiangyou Shi Xiaodong Zhang Rongchun Chen Shuaishuai Xu Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping BMC Musculoskeletal Disorders Magnetic resonance imaging T2* mapping Lumbar facet joint Intervertebral disc |
| title | Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping |
| title_full | Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping |
| title_fullStr | Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping |
| title_full_unstemmed | Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping |
| title_short | Biochemical changes in lumbar facet joint and disc degeneration by T2* mapping |
| title_sort | biochemical changes in lumbar facet joint and disc degeneration by t2 mapping |
| topic | Magnetic resonance imaging T2* mapping Lumbar facet joint Intervertebral disc |
| url | https://doi.org/10.1186/s12891-024-07265-9 |
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