Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against <i>Trypanosoma cruzi</i>

Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against <i>Trypanosoma cruzi</i>

Chagas disease (CD) still represents a serious public health problem in Latin America, even after more than 100 years of its discovery. Clinical treatments (nifurtimox and benznidazole) are considered inadequate, especially because of undesirable side effects and low efficacy in the chronic stages o...

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Bibliographic Details
Main Authors: Leonardo S. Lara, Guilherme C. Lechuga, Caroline dos S. Moreira, Thaís B. Santos, Vitor F. Ferreira, David R. da Rocha, Mirian C. S. Pereira
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
<i>Trypanosoma cruzi</i>
naphthoquinones
trypanocidal activity
chemotherapy
compound optimization
Online Access:https://www.mdpi.com/1420-3049/26/2/423

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