A Sensitivity Analysis Comparison of Three Models for the Dynamics of Germinal Centers

A Sensitivity Analysis Comparison of Three Models for the Dynamics of Germinal Centers

Germinal centers (GCs) are transient anatomical microenvironments where antibody affinity maturation and memory B cells generation takes place. In the past, models of Germinal Center (GC) dynamics have focused on understanding antibody affinity maturation rather than on the main mechanism(s) driving...

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Bibliographic Details
Main Authors: Jose Faro, Bernardo von Haeften, Rui Gardner, Emilio Faro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
germinal center dynamics
mathematical model analysis
parameter sensitivity analysis
LHS method
regulation of germinal center dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02038/full

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