Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study
IntroductionRecent research highlights the significance of insomnia and sleepiness, shifting from obstructive sleep apnea (OSA) severity and sleep structure, in defining OSA phenotypes.ObjectivesThis study aimed to characterize insomnia and sleepiness associated with OSA phenotypes and assess their...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1303778/full |
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| author | Agata Gabryelska Szymon Turkiewicz Piotr Białasiewicz Filip Grzybowski Dominik Strzelecki Marcin Sochal |
| author_facet | Agata Gabryelska Szymon Turkiewicz Piotr Białasiewicz Filip Grzybowski Dominik Strzelecki Marcin Sochal |
| author_sort | Agata Gabryelska |
| collection | DOAJ |
| description | IntroductionRecent research highlights the significance of insomnia and sleepiness, shifting from obstructive sleep apnea (OSA) severity and sleep structure, in defining OSA phenotypes.ObjectivesThis study aimed to characterize insomnia and sleepiness associated with OSA phenotypes and assess their involvement in depression symptoms (DS) in OSA.Materials and methodsThis cross-sectional, clinical study included 181 participants who underwent polysomnography (PSG) and filled out questionnaires, including the Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Index (BDI). They were categorized into phenotypes: insomnia–sleepiness (I + S; ESS ≥ 11; ISI ≥ 15; n = 20), sleepiness (S; ESS ≥ 11; ISI < 15; n = 22), insomnia (I; ESS < 11; ISI ≥ 15), and asymptomatic (A; ESS < 11; ISI<15; n=55).ResultsA linear regression model for the BDI score (R2 = 0.357, p < 0.001) included ISI score and subjective-to-objective sleep latency ratio. The ISI score was a predictive factor for mild and moderate DS [OR = 1.23 (95% CI: 1.09–1.38), p < 0.001 and OR = 1.39 (95% CI: 1.13–1.72), p = 0.002]. The I and I + S phenotypes are characterized by higher BDI scores (p < 0.001 and p = 0.02), longer subjective sleep latency (p = 0.008 and p = 0.04), and shorter subjective total sleep time (TST; p = 0.049 and p = 0.006) compared to A. Furthermore, the I and I + S groups had shorter subjective TST than S (p = 0.03 and p = 0.047). The I and I + S had higher BDI scores than A (p < 0.001 and p = 0.02, respectively) and S (p < 0.001 and p = 0.02, respectively). The I phenotype was associated with the risk of mild and moderate DS (OR = 5.61 (95% CI: 1.91–16.53), p < 0.001 and OR = 9.55 (95% CI: 1.81–50.48), p = 0.008 respectively). Moreover, the I + S phenotype presented an even greater risk for mild DS (OR = 10.29 (95% CI: 2.95–35.85), p < 0.001).ConclusionUsing clinical features for OSA phenotyping holds promise for finding OSA individuals with increased risk for DS occurrence. |
| first_indexed | 2024-03-07T19:10:10Z |
| format | Article |
| id | doaj.art-38d011b0cc0f421eaae82577c168fcb0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-07T19:10:10Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-38d011b0cc0f421eaae82577c168fcb02024-03-01T04:27:26ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-03-011510.3389/fpsyt.2024.13037781303778Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical studyAgata Gabryelska0Szymon Turkiewicz1Piotr Białasiewicz2Filip Grzybowski3Dominik Strzelecki4Marcin Sochal5Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, PolandIntroductionRecent research highlights the significance of insomnia and sleepiness, shifting from obstructive sleep apnea (OSA) severity and sleep structure, in defining OSA phenotypes.ObjectivesThis study aimed to characterize insomnia and sleepiness associated with OSA phenotypes and assess their involvement in depression symptoms (DS) in OSA.Materials and methodsThis cross-sectional, clinical study included 181 participants who underwent polysomnography (PSG) and filled out questionnaires, including the Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Index (BDI). They were categorized into phenotypes: insomnia–sleepiness (I + S; ESS ≥ 11; ISI ≥ 15; n = 20), sleepiness (S; ESS ≥ 11; ISI < 15; n = 22), insomnia (I; ESS < 11; ISI ≥ 15), and asymptomatic (A; ESS < 11; ISI<15; n=55).ResultsA linear regression model for the BDI score (R2 = 0.357, p < 0.001) included ISI score and subjective-to-objective sleep latency ratio. The ISI score was a predictive factor for mild and moderate DS [OR = 1.23 (95% CI: 1.09–1.38), p < 0.001 and OR = 1.39 (95% CI: 1.13–1.72), p = 0.002]. The I and I + S phenotypes are characterized by higher BDI scores (p < 0.001 and p = 0.02), longer subjective sleep latency (p = 0.008 and p = 0.04), and shorter subjective total sleep time (TST; p = 0.049 and p = 0.006) compared to A. Furthermore, the I and I + S groups had shorter subjective TST than S (p = 0.03 and p = 0.047). The I and I + S had higher BDI scores than A (p < 0.001 and p = 0.02, respectively) and S (p < 0.001 and p = 0.02, respectively). The I phenotype was associated with the risk of mild and moderate DS (OR = 5.61 (95% CI: 1.91–16.53), p < 0.001 and OR = 9.55 (95% CI: 1.81–50.48), p = 0.008 respectively). Moreover, the I + S phenotype presented an even greater risk for mild DS (OR = 10.29 (95% CI: 2.95–35.85), p < 0.001).ConclusionUsing clinical features for OSA phenotyping holds promise for finding OSA individuals with increased risk for DS occurrence.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1303778/fullinsomniaphenotypingOSAdepressionexcessive daytime sleepiness |
| spellingShingle | Agata Gabryelska Szymon Turkiewicz Piotr Białasiewicz Filip Grzybowski Dominik Strzelecki Marcin Sochal Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study Frontiers in Psychiatry insomnia phenotyping OSA depression excessive daytime sleepiness |
| title | Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study |
| title_full | Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study |
| title_fullStr | Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study |
| title_full_unstemmed | Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study |
| title_short | Evaluation of daytime sleepiness and insomnia symptoms in OSA patients with a characterization of symptom-defined phenotypes and their involvement in depression comorbidity—a cross-sectional clinical study |
| title_sort | evaluation of daytime sleepiness and insomnia symptoms in osa patients with a characterization of symptom defined phenotypes and their involvement in depression comorbidity a cross sectional clinical study |
| topic | insomnia phenotyping OSA depression excessive daytime sleepiness |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1303778/full |
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