Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women
Background & objectives: Local angiogenesis in endometrium has been shown to be an essential pre-requisite for endometrial receptivity needed for implantation and gestation. Recently, numerous diagnostic gears have been projected to 'measure' or 'estimate' the endometrial rec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Medical Research |
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| Online Access: | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2021;volume=154;issue=1;spage=99;epage=107;aulast=Singh |
| _version_ | 1797995716399857664 |
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| author | Monisha Singh Neema Acharya Samarth Shukla Deepti Shrivastava Gaurav Sharma |
| author_facet | Monisha Singh Neema Acharya Samarth Shukla Deepti Shrivastava Gaurav Sharma |
| author_sort | Monisha Singh |
| collection | DOAJ |
| description | Background & objectives: Local angiogenesis in endometrium has been shown to be an essential pre-requisite for endometrial receptivity needed for implantation and gestation. Recently, numerous diagnostic gears have been projected to 'measure' or 'estimate' the endometrial receptivity relying upon angiogenic factors helping throughout implantation. This study evaluated the endometrial and subendometrial blood flow and the local endometrial gland vascular endothelial growth factor (EG-VEGF) expression as markers of local angiogenesis.
Methods: The present study was done to give quantitative assessment of endometrial thickness (ET), endometrial blood flow and subendometrial blood flow colour Doppler indices with endometrial vascular zones. Endometrial biopsy was taken and with VEGF stained and scored with immunohistochemistry.
Results: The mean ET for fertile women was 9.41 mm, while in unexplained infertile women it was around 7.90 mm. Upon comparison of ET with EG-VEGF which is considered as a gold standard with correlation coefficient, the present study suggested a positive correlation of EG-VEGF with ET, endometrial pulsatility index (PI), and subendometrial PI also the vascular zones were considered as significant. However, a strong negative correlation was seen with subendometrial resistivity index and PI.
Interpretation & conclusions: The present study suggests that uterine ultrasound, uterine colour Doppler and EG-VEGF are parameters which can be used as markers of local angiogenesis for endometrial receptivity in the evaluation of women with unexplained infertility. |
| first_indexed | 2024-04-11T10:06:03Z |
| format | Article |
| id | doaj.art-38d09f33dd6f4b3296ae34c5acc4c7fe |
| institution | Directory Open Access Journal |
| issn | 0971-5916 |
| language | English |
| last_indexed | 2024-04-11T10:06:03Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Research |
| spelling | doaj.art-38d09f33dd6f4b3296ae34c5acc4c7fe2022-12-22T04:30:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Research0971-59162021-01-0115419910710.4103/ijmr.IJMR_2331_18Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile womenMonisha SinghNeema AcharyaSamarth ShuklaDeepti ShrivastavaGaurav SharmaBackground & objectives: Local angiogenesis in endometrium has been shown to be an essential pre-requisite for endometrial receptivity needed for implantation and gestation. Recently, numerous diagnostic gears have been projected to 'measure' or 'estimate' the endometrial receptivity relying upon angiogenic factors helping throughout implantation. This study evaluated the endometrial and subendometrial blood flow and the local endometrial gland vascular endothelial growth factor (EG-VEGF) expression as markers of local angiogenesis. Methods: The present study was done to give quantitative assessment of endometrial thickness (ET), endometrial blood flow and subendometrial blood flow colour Doppler indices with endometrial vascular zones. Endometrial biopsy was taken and with VEGF stained and scored with immunohistochemistry. Results: The mean ET for fertile women was 9.41 mm, while in unexplained infertile women it was around 7.90 mm. Upon comparison of ET with EG-VEGF which is considered as a gold standard with correlation coefficient, the present study suggested a positive correlation of EG-VEGF with ET, endometrial pulsatility index (PI), and subendometrial PI also the vascular zones were considered as significant. However, a strong negative correlation was seen with subendometrial resistivity index and PI. Interpretation & conclusions: The present study suggests that uterine ultrasound, uterine colour Doppler and EG-VEGF are parameters which can be used as markers of local angiogenesis for endometrial receptivity in the evaluation of women with unexplained infertility.http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2021;volume=154;issue=1;spage=99;epage=107;aulast=Singhangiogenesis - doppler - vegf - implantation - unexplained infertility |
| spellingShingle | Monisha Singh Neema Acharya Samarth Shukla Deepti Shrivastava Gaurav Sharma Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women Indian Journal of Medical Research angiogenesis - doppler - vegf - implantation - unexplained infertility |
| title | Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| title_full | Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| title_fullStr | Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| title_full_unstemmed | Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| title_short | Comparative study of endometrial & subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| title_sort | comparative study of endometrial subendometrial angiogenesis in unexplained infertile versus normal fertile women |
| topic | angiogenesis - doppler - vegf - implantation - unexplained infertility |
| url | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2021;volume=154;issue=1;spage=99;epage=107;aulast=Singh |
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