Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial
Introduction Cancer-related cognitive impairment is common among people diagnosed with and treated for cancer. This can be a distressing and disabling side effect for impacted individuals. Interventions to mitigate cognitive dysfunction are available, but, to date, most have been trialled in samples...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/4/e081084.full |
| _version_ | 1797194718486986752 |
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| author | Victoria White Patricia M Livingston Meinir Krishnasamy Anna Ugalde Haryana Dhillon Karla Gough Priscilla Gates Janette L Vardy Karen Caeyenberghs Michael Dickinson Heather J Green Jade Guarnera |
| author_facet | Victoria White Patricia M Livingston Meinir Krishnasamy Anna Ugalde Haryana Dhillon Karla Gough Priscilla Gates Janette L Vardy Karen Caeyenberghs Michael Dickinson Heather J Green Jade Guarnera |
| author_sort | Victoria White |
| collection | DOAJ |
| description | Introduction Cancer-related cognitive impairment is common among people diagnosed with and treated for cancer. This can be a distressing and disabling side effect for impacted individuals. Interventions to mitigate cognitive dysfunction are available, but, to date, most have been trialled in samples that are largely or exclusively composed of people with solid tumours. Intervention strategies to support cognitive functioning are needed, but there is a paucity of research in this area. The main aim of this study is to test the feasibility and acceptability of methods and procedures intended for use in a definitive trial of a web-based cognitive rehabilitation programme, Responding to Cognitive Concerns (eReCog), in people who have received chemotherapy for aggressive lymphoma.Methods and analysis The proposed study is a single-site, parallel-group, pilot randomised controlled trial, with one baseline and one follow-up (or postintervention) assessment. 38 people from the target population with low perceived cognitive function based on the Cognitive Change Screen will be recruited from a specialist cancer centre between July 2023 and June 2024. After baseline assessment, participants will be randomised one-to-one to receive usual care only (a factsheet about changes in memory and thinking for people with cancer) or eReCog plus usual care. The 4-week eReCog intervention consists of four online modules offering psychoeducation on cognitive impairment associated with cancer and its treatment, skills training for improving memory, and attention and relaxation training. Study outcomes will include the feasibility of recruitment and retention at follow-up assessment (primary outcomes), as well as adherence to, usability of and intrinsic motivation to engage with eReCog, and compliance with study measures. The potential efficacy of eReCog will also be evaluated.Ethics and dissemination Ethical approval was granted by the Peter MacCallum Cancer Centre Human Research Ethics Committee in Victoria, Australia (HREC/97384/PMCC). Study findings will be disseminated via peer-reviewed publications and conference presentations.Trial registration number Australian New Zealand Clinical Trials Registry, ACTRN12623000705684. |
| first_indexed | 2024-04-24T06:00:44Z |
| format | Article |
| id | doaj.art-38d0f791a4aa4b94bef96ae55ab095f4 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-24T06:00:44Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-38d0f791a4aa4b94bef96ae55ab095f42024-04-23T07:55:09ZengBMJ Publishing GroupBMJ Open2044-60552024-04-0114410.1136/bmjopen-2023-081084Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trialVictoria White0Patricia M Livingston1Meinir Krishnasamy2Anna Ugalde3Haryana Dhillon4Karla Gough5Priscilla Gates6Janette L Vardy7Karen Caeyenberghs8Michael Dickinson9Heather J Green10Jade Guarnera119 Faculty of Health, Deakin University, Burwood, Victoria, AustraliaFaculty of Health, Deakin University, Burwood, Victoria, Australia4 Department of Nursing, The University of Melbourne, Melbourne, Victoria, AustraliaInstitute for Health Transformation, Deakin University, Burwood, Victoria, AustraliaCeMPED, The University of Sydney, Sydney, New South Wales, Australia3 Department of Cancer Experiences, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia1 Department of Clinical Haematology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Melbourne, Victoria, Australia10 Medical Oncology, Concord Repatriation General Hospital, Concord, New South Wales, AustraliaSchool of Psychology, Deakin University, Geelong, Victoria, Australia4 Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia3 Faculty of Health, Griffith University, Gold Coast, Queensland, Australia1 Cognitive Neuroscience Unit, Deakin University, Burwood, Victoria, AustraliaIntroduction Cancer-related cognitive impairment is common among people diagnosed with and treated for cancer. This can be a distressing and disabling side effect for impacted individuals. Interventions to mitigate cognitive dysfunction are available, but, to date, most have been trialled in samples that are largely or exclusively composed of people with solid tumours. Intervention strategies to support cognitive functioning are needed, but there is a paucity of research in this area. The main aim of this study is to test the feasibility and acceptability of methods and procedures intended for use in a definitive trial of a web-based cognitive rehabilitation programme, Responding to Cognitive Concerns (eReCog), in people who have received chemotherapy for aggressive lymphoma.Methods and analysis The proposed study is a single-site, parallel-group, pilot randomised controlled trial, with one baseline and one follow-up (or postintervention) assessment. 38 people from the target population with low perceived cognitive function based on the Cognitive Change Screen will be recruited from a specialist cancer centre between July 2023 and June 2024. After baseline assessment, participants will be randomised one-to-one to receive usual care only (a factsheet about changes in memory and thinking for people with cancer) or eReCog plus usual care. The 4-week eReCog intervention consists of four online modules offering psychoeducation on cognitive impairment associated with cancer and its treatment, skills training for improving memory, and attention and relaxation training. Study outcomes will include the feasibility of recruitment and retention at follow-up assessment (primary outcomes), as well as adherence to, usability of and intrinsic motivation to engage with eReCog, and compliance with study measures. The potential efficacy of eReCog will also be evaluated.Ethics and dissemination Ethical approval was granted by the Peter MacCallum Cancer Centre Human Research Ethics Committee in Victoria, Australia (HREC/97384/PMCC). Study findings will be disseminated via peer-reviewed publications and conference presentations.Trial registration number Australian New Zealand Clinical Trials Registry, ACTRN12623000705684.https://bmjopen.bmj.com/content/14/4/e081084.full |
| spellingShingle | Victoria White Patricia M Livingston Meinir Krishnasamy Anna Ugalde Haryana Dhillon Karla Gough Priscilla Gates Janette L Vardy Karen Caeyenberghs Michael Dickinson Heather J Green Jade Guarnera Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial BMJ Open |
| title | Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial |
| title_full | Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial |
| title_fullStr | Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial |
| title_full_unstemmed | Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial |
| title_short | Web-based cognitive rehabilitation intervention for cancer-related cognitive impairment following chemotherapy for aggressive lymphoma: protocol for a randomised pilot trial |
| title_sort | web based cognitive rehabilitation intervention for cancer related cognitive impairment following chemotherapy for aggressive lymphoma protocol for a randomised pilot trial |
| url | https://bmjopen.bmj.com/content/14/4/e081084.full |
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