Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus
Abstract Background The current study aimed to reveal the correlation of beta-cell function and insulin sensitivity with glycemic control and weight control before and after medical nutrition therapy (MNT) in patients with newly-diagnosed type 2 diabetes mellitus. Methods We retrospectively analyzed...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01064-w |
| _version_ | 1811241311821365248 |
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| author | Mitsuyoshi Takahara Toshihiko Shiraiwa Yoshifumi Maeno Kaoru Yamamoto Yuka Shiraiwa Yoko Yoshida Norio Nishioka Naoto Katakami Iichiro Shimomura |
| author_facet | Mitsuyoshi Takahara Toshihiko Shiraiwa Yoshifumi Maeno Kaoru Yamamoto Yuka Shiraiwa Yoko Yoshida Norio Nishioka Naoto Katakami Iichiro Shimomura |
| author_sort | Mitsuyoshi Takahara |
| collection | DOAJ |
| description | Abstract Background The current study aimed to reveal the correlation of beta-cell function and insulin sensitivity with glycemic control and weight control before and after medical nutrition therapy (MNT) in patients with newly-diagnosed type 2 diabetes mellitus. Methods We retrospectively analyzed consecutive 68 patients with newly-diagnosed type 2 diabetes mellitus who started MNT without antihyperglycemic medications and underwent a 75-g oral glucose tolerance test (OGTT) before and after the therapy. Beta-cell function was evaluated by the OGTT-derived disposition index, whereas insulin sensitivity was evaluated by Matsuda’s insulin sensitivity index. Results After 4.0 ± 1.5 months of MNT, mean HbA1c and body mass index significantly decreased from 9.6 ± 1.8% to 7.2 ± 1.0% and from 26.9 ± 4.1 to 25.4 ± 3.7 kg/m2 (both P < 0.001), while the median disposition index and Matsuda’s index significantly increased from 0.34 (0.20–0.68) to 0.88 (0.53–1.52) (P < 0.001) and from 4.70 (2.95–5.93) to 5.17 (3.48–6.89) (P = 0.003), respectively. The disposition index was significantly correlated with HbA1c levels both before and after MNT (r = -0.61 and -0.68; both P < 0.001). The magnitude of the correlation after MNT was not different from that before MNT (P = 0.42). Matsuda’s index was correlated not with HbA1c levels but with body mass index, both before (r = 0.07 [P = 0.57] and r = -0.58 [P < 0.001]) and after MNT (r = -0.01 [P = 0.95] and r = -0.52 [P < 0.001]). Conclusions Beta-cell function was improved in conjunction with glycemic control after MNT in patients with newly-diagnosed type 2 diabetes mellitus. Insulin sensitivity was linked with weight control rather than glycemic control. |
| first_indexed | 2024-04-12T13:34:29Z |
| format | Article |
| id | doaj.art-38d21f179a4144f28cbca3eb94336bb0 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-12T13:34:29Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-38d21f179a4144f28cbca3eb94336bb02022-12-22T03:31:03ZengBMCBMC Endocrine Disorders1472-68232022-06-012211810.1186/s12902-022-01064-wImprovement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitusMitsuyoshi Takahara0Toshihiko Shiraiwa1Yoshifumi Maeno2Kaoru Yamamoto3Yuka Shiraiwa4Yoko Yoshida5Norio Nishioka6Naoto Katakami7Iichiro Shimomura8Department of Diabetes Care Medicine, Osaka University Graduate School of MedicineShiraiwa Medical ClinicShiraiwa Medical ClinicShiraiwa Medical ClinicShiraiwa Medical ClinicShiraiwa Medical ClinicShiraiwa Medical ClinicDepartment of Metabolic Medicine, Osaka University Graduate School of MedicineDepartment of Metabolic Medicine, Osaka University Graduate School of MedicineAbstract Background The current study aimed to reveal the correlation of beta-cell function and insulin sensitivity with glycemic control and weight control before and after medical nutrition therapy (MNT) in patients with newly-diagnosed type 2 diabetes mellitus. Methods We retrospectively analyzed consecutive 68 patients with newly-diagnosed type 2 diabetes mellitus who started MNT without antihyperglycemic medications and underwent a 75-g oral glucose tolerance test (OGTT) before and after the therapy. Beta-cell function was evaluated by the OGTT-derived disposition index, whereas insulin sensitivity was evaluated by Matsuda’s insulin sensitivity index. Results After 4.0 ± 1.5 months of MNT, mean HbA1c and body mass index significantly decreased from 9.6 ± 1.8% to 7.2 ± 1.0% and from 26.9 ± 4.1 to 25.4 ± 3.7 kg/m2 (both P < 0.001), while the median disposition index and Matsuda’s index significantly increased from 0.34 (0.20–0.68) to 0.88 (0.53–1.52) (P < 0.001) and from 4.70 (2.95–5.93) to 5.17 (3.48–6.89) (P = 0.003), respectively. The disposition index was significantly correlated with HbA1c levels both before and after MNT (r = -0.61 and -0.68; both P < 0.001). The magnitude of the correlation after MNT was not different from that before MNT (P = 0.42). Matsuda’s index was correlated not with HbA1c levels but with body mass index, both before (r = 0.07 [P = 0.57] and r = -0.58 [P < 0.001]) and after MNT (r = -0.01 [P = 0.95] and r = -0.52 [P < 0.001]). Conclusions Beta-cell function was improved in conjunction with glycemic control after MNT in patients with newly-diagnosed type 2 diabetes mellitus. Insulin sensitivity was linked with weight control rather than glycemic control.https://doi.org/10.1186/s12902-022-01064-wDisposition indexHemoglobin A1cMedical nutrition therapyNewly-diagnosed type 2 diabetes mellitus |
| spellingShingle | Mitsuyoshi Takahara Toshihiko Shiraiwa Yoshifumi Maeno Kaoru Yamamoto Yuka Shiraiwa Yoko Yoshida Norio Nishioka Naoto Katakami Iichiro Shimomura Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus BMC Endocrine Disorders Disposition index Hemoglobin A1c Medical nutrition therapy Newly-diagnosed type 2 diabetes mellitus |
| title | Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus |
| title_full | Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus |
| title_fullStr | Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus |
| title_full_unstemmed | Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus |
| title_short | Improvement of beta-cell function in conjunction with glycemic control after medical nutrition therapy in newly-diagnosed type 2 diabetes mellitus |
| title_sort | improvement of beta cell function in conjunction with glycemic control after medical nutrition therapy in newly diagnosed type 2 diabetes mellitus |
| topic | Disposition index Hemoglobin A1c Medical nutrition therapy Newly-diagnosed type 2 diabetes mellitus |
| url | https://doi.org/10.1186/s12902-022-01064-w |
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