A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment
Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/9/24/3323 |
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| author | Rami Zakh Alexander Churkin William Bietsch Menachem Lachiany Scott J. Cotler Alexander Ploss Harel Dahari Danny Barash |
| author_facet | Rami Zakh Alexander Churkin William Bietsch Menachem Lachiany Scott J. Cotler Alexander Ploss Harel Dahari Danny Barash |
| author_sort | Rami Zakh |
| collection | DOAJ |
| description | Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy. |
| first_indexed | 2024-03-10T03:36:59Z |
| format | Article |
| id | doaj.art-38d234b459304f6393b81f3c49283edf |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-10T03:36:59Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-38d234b459304f6393b81f3c49283edf2023-11-23T09:27:29ZengMDPI AGMathematics2227-73902021-12-01924332310.3390/math9243323A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV TreatmentRami Zakh0Alexander Churkin1William Bietsch2Menachem Lachiany3Scott J. Cotler4Alexander Ploss5Harel Dahari6Danny Barash7Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, IsraelDepartment of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 8410501, IsraelStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USACampus Lev, Jerusalem College of Technology, Jerusalem 91160, IsraelStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USADepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USAStritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USADepartment of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, IsraelHepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.https://www.mdpi.com/2227-7390/9/24/3323hepatitis delta virusHDV-HBV coinfectionviral kinetic models |
| spellingShingle | Rami Zakh Alexander Churkin William Bietsch Menachem Lachiany Scott J. Cotler Alexander Ploss Harel Dahari Danny Barash A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment Mathematics hepatitis delta virus HDV-HBV coinfection viral kinetic models |
| title | A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment |
| title_full | A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment |
| title_fullStr | A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment |
| title_full_unstemmed | A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment |
| title_short | A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment |
| title_sort | mathematical model for early hbv and hdv kinetics during anti hdv treatment |
| topic | hepatitis delta virus HDV-HBV coinfection viral kinetic models |
| url | https://www.mdpi.com/2227-7390/9/24/3323 |
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