Neuronal Adenosine A1 Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation

Neuronal Adenosine A1 Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation

Adenine nucleotides, such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), as well as the nucleoside adenosine are important modulators of neuronal function by engaging P1 and P2 purinergic receptors. In mitral cells, signaling of the G protein-coupled P1 receptor adenosine 1 receptor (...

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Bibliographic Details
Main Authors: Charlotte Schubert, Kristina Schulz, Simone Träger, Anna-Lena Plath, Asina Omriouate, Sina C. Rosenkranz, Fabio Morellini, Manuel A. Friese, Daniela Hirnet
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
adenosine
A1R
purinergic signaling
EAE
olfactory bulb
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.912030/full

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