Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population
Abstract Background The prevalence of diabetes and prediabetes were estimated to be 10.9% and 35.7% in the Chinese adult population, respectively, and the middle-aged and elderly Chinese are at even higher risk of diabetes and prediabetes than younger population. With the increasing trend of aging i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-019-0418-x |
| _version_ | 1818275076370333696 |
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| author | Xueli Cai Lili Xia Yuesong Pan Dian He Huiping Zhu Tiemin Wei Yan He |
| author_facet | Xueli Cai Lili Xia Yuesong Pan Dian He Huiping Zhu Tiemin Wei Yan He |
| author_sort | Xueli Cai |
| collection | DOAJ |
| description | Abstract Background The prevalence of diabetes and prediabetes were estimated to be 10.9% and 35.7% in the Chinese adult population, respectively, and the middle-aged and elderly Chinese are at even higher risk of diabetes and prediabetes than younger population. With the increasing trend of aging in China, the burden of diabetes and related complications will be aggravated. Objectives Through comparing the indices of insulin resistance and β-cell function between subjects with different glucose metabolic status, to analyze the differential role of insulin resistance and β-cell function in the development of prediabetes and type 2 diabetes (T2DM) in the middle-aged and elderly Chinese population. Methods In this cross-sectional study, we enrolled 512 participants aged 50 and over. The indices of insulin resistance (homoeostasis model assessment of insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR), and indices of β-cell function [HOMA-β), fasting C-peptide to glucose ratio (FCPRI) and postprandial C-peptide to glucose ratio (PCPRI)] were calculated. Association of insulin resistance and β-cell function with prediabetes or T2DM were evaluated by multivariate logistic regression analysis, in which potential confounding factors were adjusted. Results Of the 509 participants with complete information, 263 (51.7%) had normal glucose tolerance (NGT), 161 (31.6%) were in prediabetic status and 85 (16.7%) were overt T2DM. With the advancing of unfavorable glucose metabolism, the insulin resistance (HOMA-IR and Adipo-IR) and β-cell function (FCPRI, PCPRI) deteriorated (P trend < 0.05 for all indices). We found that increase in insulin resistance expressed by Adipo-IR and HOMA-IR is associated with increased risk of prediabetes, whereas decrease in β-cell function expressed by HOMA-β and PCPRI is associated with increased risk of T2DM. We also demonstrated that Adipo-IR was more closely associated with developing prediabetes than HOMA-IR, and PCPRI was most closely related with developing T2DM among the indices of β-cell function used in this study. Conclusions Insulin resistance is the main determinant of developing prediabetes, whereas β-cell function is the main determinant of developing T2DM. |
| first_indexed | 2024-12-12T22:24:00Z |
| format | Article |
| id | doaj.art-38d520eb90934afaad1a32148a6d8955 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-12T22:24:00Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-38d520eb90934afaad1a32148a6d89552022-12-22T00:09:49ZengBMCDiabetology & Metabolic Syndrome1758-59962019-03-011111810.1186/s13098-019-0418-xDifferential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese populationXueli Cai0Lili Xia1Yuesong Pan2Dian He3Huiping Zhu4Tiemin Wei5Yan He6Department of Neurology, Lishui Municipal Central HospitalEditorial Office of Hepatobiliary and Pancreatic Diseases International, the First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Epidemiology and Biostatics, School of Public Health, Capital Medical UniversityDepartment of Epidemiology and Biostatics, School of Public Health, Capital Medical UniversityDepartment of Neurology, Lishui Municipal Central HospitalDepartment of Epidemiology and Biostatics, School of Public Health, Capital Medical UniversityAbstract Background The prevalence of diabetes and prediabetes were estimated to be 10.9% and 35.7% in the Chinese adult population, respectively, and the middle-aged and elderly Chinese are at even higher risk of diabetes and prediabetes than younger population. With the increasing trend of aging in China, the burden of diabetes and related complications will be aggravated. Objectives Through comparing the indices of insulin resistance and β-cell function between subjects with different glucose metabolic status, to analyze the differential role of insulin resistance and β-cell function in the development of prediabetes and type 2 diabetes (T2DM) in the middle-aged and elderly Chinese population. Methods In this cross-sectional study, we enrolled 512 participants aged 50 and over. The indices of insulin resistance (homoeostasis model assessment of insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR), and indices of β-cell function [HOMA-β), fasting C-peptide to glucose ratio (FCPRI) and postprandial C-peptide to glucose ratio (PCPRI)] were calculated. Association of insulin resistance and β-cell function with prediabetes or T2DM were evaluated by multivariate logistic regression analysis, in which potential confounding factors were adjusted. Results Of the 509 participants with complete information, 263 (51.7%) had normal glucose tolerance (NGT), 161 (31.6%) were in prediabetic status and 85 (16.7%) were overt T2DM. With the advancing of unfavorable glucose metabolism, the insulin resistance (HOMA-IR and Adipo-IR) and β-cell function (FCPRI, PCPRI) deteriorated (P trend < 0.05 for all indices). We found that increase in insulin resistance expressed by Adipo-IR and HOMA-IR is associated with increased risk of prediabetes, whereas decrease in β-cell function expressed by HOMA-β and PCPRI is associated with increased risk of T2DM. We also demonstrated that Adipo-IR was more closely associated with developing prediabetes than HOMA-IR, and PCPRI was most closely related with developing T2DM among the indices of β-cell function used in this study. Conclusions Insulin resistance is the main determinant of developing prediabetes, whereas β-cell function is the main determinant of developing T2DM.http://link.springer.com/article/10.1186/s13098-019-0418-xAdipose tissue insulin resistancePeripheral tissue insulin resistanceβ-Cell functionPrediabetesType 2 diabetes |
| spellingShingle | Xueli Cai Lili Xia Yuesong Pan Dian He Huiping Zhu Tiemin Wei Yan He Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population Diabetology & Metabolic Syndrome Adipose tissue insulin resistance Peripheral tissue insulin resistance β-Cell function Prediabetes Type 2 diabetes |
| title | Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population |
| title_full | Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population |
| title_fullStr | Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population |
| title_full_unstemmed | Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population |
| title_short | Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population |
| title_sort | differential role of insulin resistance and β cell function in the development of prediabetes and diabetes in middle aged and elderly chinese population |
| topic | Adipose tissue insulin resistance Peripheral tissue insulin resistance β-Cell function Prediabetes Type 2 diabetes |
| url | http://link.springer.com/article/10.1186/s13098-019-0418-x |
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