Single molecule analysis reveals reversible and irreversible steps during spliceosome activation

Single molecule analysis reveals reversible and irreversible steps during spliceosome activation

The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated...

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Bibliographic Details
Main Authors: Aaron A Hoskins, Margaret L Rodgers, Larry J Friedman, Jeff Gelles, Melissa J Moore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
splicing
spliceosome
snRNP
single-molecule
fluorescence
RNA
Online Access:https://elifesciences.org/articles/14166

Internet

https://elifesciences.org/articles/14166

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