RPA, RFWD3 and BRCA2 at stalled forks: a balancing act
We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee fork repair. These findings provide new insig...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1801089 |
| _version_ | 1797677066202644480 |
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| author | Haohui Duan Shailja Pathania |
| author_facet | Haohui Duan Shailja Pathania |
| author_sort | Haohui Duan |
| collection | DOAJ |
| description | We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee fork repair. These findings provide new insights into the workings of BRCA1 and BRCA2 in the stalled fork repair pathway. |
| first_indexed | 2024-03-11T22:39:39Z |
| format | Article |
| id | doaj.art-38d73af2d1344ffba7d9cdaff026b32a |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:39Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-38d73af2d1344ffba7d9cdaff026b32a2023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-11-017610.1080/23723556.2020.18010891801089RPA, RFWD3 and BRCA2 at stalled forks: a balancing actHaohui Duan0Shailja Pathania1University of MassachusettsUniversity of MassachusettsWe recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee fork repair. These findings provide new insights into the workings of BRCA1 and BRCA2 in the stalled fork repair pathway.http://dx.doi.org/10.1080/23723556.2020.1801089brca2replication stressrfwd3rpa ubiquitinationbrca1mre11smarcal1 |
| spellingShingle | Haohui Duan Shailja Pathania RPA, RFWD3 and BRCA2 at stalled forks: a balancing act Molecular & Cellular Oncology brca2 replication stress rfwd3 rpa ubiquitination brca1 mre11 smarcal1 |
| title | RPA, RFWD3 and BRCA2 at stalled forks: a balancing act |
| title_full | RPA, RFWD3 and BRCA2 at stalled forks: a balancing act |
| title_fullStr | RPA, RFWD3 and BRCA2 at stalled forks: a balancing act |
| title_full_unstemmed | RPA, RFWD3 and BRCA2 at stalled forks: a balancing act |
| title_short | RPA, RFWD3 and BRCA2 at stalled forks: a balancing act |
| title_sort | rpa rfwd3 and brca2 at stalled forks a balancing act |
| topic | brca2 replication stress rfwd3 rpa ubiquitination brca1 mre11 smarcal1 |
| url | http://dx.doi.org/10.1080/23723556.2020.1801089 |
| work_keys_str_mv | AT haohuiduan rparfwd3andbrca2atstalledforksabalancingact AT shailjapathania rparfwd3andbrca2atstalledforksabalancingact |