Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds
The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-relate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/12/2052 |
| _version_ | 1827575817549381632 |
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| author | Anna Rybarczyk Aleksandra Majchrzak-Celińska Violetta Krajka-Kuźniak |
| author_facet | Anna Rybarczyk Aleksandra Majchrzak-Celińska Violetta Krajka-Kuźniak |
| author_sort | Anna Rybarczyk |
| collection | DOAJ |
| description | The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, regulates the cellular defense against oxidative stress and inflammation, making it a promising cancer prevention and treatment target. Cannabinoids have demonstrated anti-tumor and anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased oxidative stress following exposure to anti-cancer therapy prompts cancer cells to activate antioxidant mechanisms. This indicates the dual effect of Nrf2 in cancer cells—influencing proliferation and apoptotic processes and protecting against the toxicity of anti-cancer therapy. Therefore, understanding the complex role of cannabinoids in modulating Nrf2 might shed light on its potential implementation as an anti-cancer support. In this review, we aim to highlight the impact of cannabinoids on Nrf2-related factors, with a focus on cancer prevention and treatment. Additionally, we have presented the results of several research studies that combined cannabidiol (CBD) with other compounds targeting Nrf2. Further studies should be directed toward exploring the anti-inflammatory effects of cannabinoids in the context of cancer prevention and therapy. |
| first_indexed | 2024-03-08T21:02:21Z |
| format | Article |
| id | doaj.art-38d75fad1c044598ac6f2c9526a7942e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-08T21:02:21Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-38d75fad1c044598ac6f2c9526a7942e2023-12-22T13:48:21ZengMDPI AGAntioxidants2076-39212023-11-011212205210.3390/antiox12122052Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis CompoundsAnna Rybarczyk0Aleksandra Majchrzak-Celińska1Violetta Krajka-Kuźniak2Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, PolandDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, PolandDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, PolandThe development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, regulates the cellular defense against oxidative stress and inflammation, making it a promising cancer prevention and treatment target. Cannabinoids have demonstrated anti-tumor and anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased oxidative stress following exposure to anti-cancer therapy prompts cancer cells to activate antioxidant mechanisms. This indicates the dual effect of Nrf2 in cancer cells—influencing proliferation and apoptotic processes and protecting against the toxicity of anti-cancer therapy. Therefore, understanding the complex role of cannabinoids in modulating Nrf2 might shed light on its potential implementation as an anti-cancer support. In this review, we aim to highlight the impact of cannabinoids on Nrf2-related factors, with a focus on cancer prevention and treatment. Additionally, we have presented the results of several research studies that combined cannabidiol (CBD) with other compounds targeting Nrf2. Further studies should be directed toward exploring the anti-inflammatory effects of cannabinoids in the context of cancer prevention and therapy.https://www.mdpi.com/2076-3921/12/12/2052nuclear factor erythroid 2-related factor 2 (Nrf2)cannabinoidscannabidiol (CBD)cancerinflammationoxidative stress |
| spellingShingle | Anna Rybarczyk Aleksandra Majchrzak-Celińska Violetta Krajka-Kuźniak Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds Antioxidants nuclear factor erythroid 2-related factor 2 (Nrf2) cannabinoids cannabidiol (CBD) cancer inflammation oxidative stress |
| title | Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds |
| title_full | Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds |
| title_fullStr | Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds |
| title_full_unstemmed | Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds |
| title_short | Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds |
| title_sort | targeting nrf2 signaling pathway in cancer prevention and treatment the role of cannabis compounds |
| topic | nuclear factor erythroid 2-related factor 2 (Nrf2) cannabinoids cannabidiol (CBD) cancer inflammation oxidative stress |
| url | https://www.mdpi.com/2076-3921/12/12/2052 |
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