Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine
Polydopamine (PDA) is a synthetic eumelanin polymer mimicking the biopolymer secreted by mussels to attach to surfaces with a high binding strength. It exhibits unique adhesive properties and has recently attracted considerable interest as a multifunctional thin film coating. In this study, we demon...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/12/864 |
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| author | Stefania Roberta Cicco Maria Michela Giangregorio Maria Teresa Rocchetti Ighli di Bari Claudio Mastropaolo Rossella Labarile Roberta Ragni Loreto Gesualdo Gianluca Maria Farinola Danilo Vona |
| author_facet | Stefania Roberta Cicco Maria Michela Giangregorio Maria Teresa Rocchetti Ighli di Bari Claudio Mastropaolo Rossella Labarile Roberta Ragni Loreto Gesualdo Gianluca Maria Farinola Danilo Vona |
| author_sort | Stefania Roberta Cicco |
| collection | DOAJ |
| description | Polydopamine (PDA) is a synthetic eumelanin polymer mimicking the biopolymer secreted by mussels to attach to surfaces with a high binding strength. It exhibits unique adhesive properties and has recently attracted considerable interest as a multifunctional thin film coating. In this study, we demonstrate that a PDA coating on silica- and polymer-based materials improves the entrapment and retention of uremic toxins produced in specific diseases. The low-cost natural nanotextured fossil diatomaceous earth (DE), an abundant source of mesoporous silica, and polyvinylpyrrolidone-co-Styrene (PVP-co-S), a commercial absorbent comprising polymeric particles, were easily coated with a PDA layer by oxidative polymerization of dopamine at mild basic aqueous conditions. An in-depth chemical-physical investigation of both the resulting PDA-coated materials was performed by SEM, AFM, UV-visible, Raman spectroscopy and spectroscopic ellipsometry. Finally, the obtained hybrid systems were successfully tested for the removal of two uremic toxins (indoxyl sulfate and p-cresyl sulfate) directly from patients’ sera. |
| first_indexed | 2024-03-09T15:46:32Z |
| format | Article |
| id | doaj.art-38d776b997824c938dfaf0323ad18627 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T15:46:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-38d776b997824c938dfaf0323ad186272023-11-24T18:27:07ZengMDPI AGToxins2072-66512022-12-01141286410.3390/toxins14120864Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with PolydopamineStefania Roberta Cicco0Maria Michela Giangregorio1Maria Teresa Rocchetti2Ighli di Bari3Claudio Mastropaolo4Rossella Labarile5Roberta Ragni6Loreto Gesualdo7Gianluca Maria Farinola8Danilo Vona9Consiglio Nazionale delle Ricerche, CNR-ICCOM, Via E. Orabona 4, 70126 Bari, ItalyInstitute of Nanotechnology, CNR-NANOTEC, Via Orabona 4, 70126 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Pinto 1, 71122 Foggia, ItalyDipartimento di Emergenza e Trapianto di Organi, Nefrologia, Dialisi e Unità Trapianti, Università Degli Studi di Bari “Aldo Moro”, Piazza G. Cesare 11, 70124 Bari, ItalyVisionage SRL, Via Marconi 19, 70011 Alberobello, ItalyDipartimento di Chimica, Università Degli Studi di Bari “Aldo Moro”, Via E. Orabona 4, 70126 Bari, ItalyDipartimento di Chimica, Università Degli Studi di Bari “Aldo Moro”, Via E. Orabona 4, 70126 Bari, ItalyDipartimento di Emergenza e Trapianto di Organi, Nefrologia, Dialisi e Unità Trapianti, Università Degli Studi di Bari “Aldo Moro”, Piazza G. Cesare 11, 70124 Bari, ItalyDipartimento di Chimica, Università Degli Studi di Bari “Aldo Moro”, Via E. Orabona 4, 70126 Bari, ItalyDipartimento di Chimica, Università Degli Studi di Bari “Aldo Moro”, Via E. Orabona 4, 70126 Bari, ItalyPolydopamine (PDA) is a synthetic eumelanin polymer mimicking the biopolymer secreted by mussels to attach to surfaces with a high binding strength. It exhibits unique adhesive properties and has recently attracted considerable interest as a multifunctional thin film coating. In this study, we demonstrate that a PDA coating on silica- and polymer-based materials improves the entrapment and retention of uremic toxins produced in specific diseases. The low-cost natural nanotextured fossil diatomaceous earth (DE), an abundant source of mesoporous silica, and polyvinylpyrrolidone-co-Styrene (PVP-co-S), a commercial absorbent comprising polymeric particles, were easily coated with a PDA layer by oxidative polymerization of dopamine at mild basic aqueous conditions. An in-depth chemical-physical investigation of both the resulting PDA-coated materials was performed by SEM, AFM, UV-visible, Raman spectroscopy and spectroscopic ellipsometry. Finally, the obtained hybrid systems were successfully tested for the removal of two uremic toxins (indoxyl sulfate and p-cresyl sulfate) directly from patients’ sera.https://www.mdpi.com/2072-6651/14/12/864diatomaceous earthpolyvinylpyrrolidone-co-styrenechemical functionalizationpolydopamineuremic toxinsbioremoval |
| spellingShingle | Stefania Roberta Cicco Maria Michela Giangregorio Maria Teresa Rocchetti Ighli di Bari Claudio Mastropaolo Rossella Labarile Roberta Ragni Loreto Gesualdo Gianluca Maria Farinola Danilo Vona Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine Toxins diatomaceous earth polyvinylpyrrolidone-co-styrene chemical functionalization polydopamine uremic toxins bioremoval |
| title | Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine |
| title_full | Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine |
| title_fullStr | Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine |
| title_full_unstemmed | Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine |
| title_short | Improving the In Vitro Removal of Indoxyl Sulfate and p-Cresyl Sulfate by Coating Diatomaceous Earth (DE) and Poly-vinyl-pyrrolidone-co-styrene (PVP-co-S) with Polydopamine |
| title_sort | improving the in vitro removal of indoxyl sulfate and p cresyl sulfate by coating diatomaceous earth de and poly vinyl pyrrolidone co styrene pvp co s with polydopamine |
| topic | diatomaceous earth polyvinylpyrrolidone-co-styrene chemical functionalization polydopamine uremic toxins bioremoval |
| url | https://www.mdpi.com/2072-6651/14/12/864 |
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