Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin
Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signaling molecule that is released during wounding, ther...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/27 |
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| author | Maarten A. Mees Fleur Boone Thomas Bouwen Frederik Vanaerschot Charlotte Titeca Hanna-Kaisa Vikkula Leen Catrysse Anja Vananroye Erin Koos Stelios Alexandris Sabine Rosenfeldt Samuel Eyley Joachim Koetz Geert van Loo Wim Thielemans Esther Hoste |
| author_facet | Maarten A. Mees Fleur Boone Thomas Bouwen Frederik Vanaerschot Charlotte Titeca Hanna-Kaisa Vikkula Leen Catrysse Anja Vananroye Erin Koos Stelios Alexandris Sabine Rosenfeldt Samuel Eyley Joachim Koetz Geert van Loo Wim Thielemans Esther Hoste |
| author_sort | Maarten A. Mees |
| collection | DOAJ |
| description | Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signaling molecule that is released during wounding, thereby delaying regenerative responses in the skin. Here, we show that dissolving glycyrrhizin, a potent HMGB1 inhibitor, in water results in the formation of a hydrogel with remarkable rheological properties. We demonstrate that these glycyrrhizin-based hydrogels accelerate cutaneous wound closure in normoglycemic and diabetic mice by influencing keratinocyte migration. To facilitate topical application of glycyrrhizin hydrogels on cutaneous wounds, several concentrations of glycyrrhizinic acid in water were tested for their rheological, structural, and biological properties. By varying the concentration of glycyrrhizin, these hydrogel properties can be readily tuned, enabling customized wound care. |
| first_indexed | 2024-03-09T11:28:18Z |
| format | Article |
| id | doaj.art-38dc3810a7fd4ddaa23ec3da5826d916 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:18Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-38dc3810a7fd4ddaa23ec3da5826d9162023-11-30T23:56:39ZengMDPI AGPharmaceutics1999-49232022-12-011512710.3390/pharmaceutics15010027Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse SkinMaarten A. Mees0Fleur Boone1Thomas Bouwen2Frederik Vanaerschot3Charlotte Titeca4Hanna-Kaisa Vikkula5Leen Catrysse6Anja Vananroye7Erin Koos8Stelios Alexandris9Sabine Rosenfeldt10Samuel Eyley11Joachim Koetz12Geert van Loo13Wim Thielemans14Esther Hoste15Sustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumVIB Center for Inflammation Research, Technologiepark 71, 9052 Ghent, BelgiumSustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumSustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumSustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumVIB Center for Inflammation Research, Technologiepark 71, 9052 Ghent, BelgiumVIB Center for Inflammation Research, Technologiepark 71, 9052 Ghent, BelgiumChemical Engineering Department, Soft Matter, Theology and Technology, KU Leuven, 3000 Leuven, BelgiumChemical Engineering Department, Soft Matter, Theology and Technology, KU Leuven, 3000 Leuven, BelgiumSustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumPhysical Chemistry and Bavarian Polymer Institute (BPI), University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, GermanySustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumInstitut für Chemie, Universität Potsdam, Karl-Liebknecht-Straße 24-25, 14476 Potsdam, GermanyVIB Center for Inflammation Research, Technologiepark 71, 9052 Ghent, BelgiumSustainable Materials Lab, Department of Chemical Engineering, Campus Kulak Kortrijk, KU Leuven, Etienne Sabbelaan 53, 8500 Kortrijk, BelgiumVIB Center for Inflammation Research, Technologiepark 71, 9052 Ghent, BelgiumEfficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat. High-mobility group box 1 (HMGB1) is an important signaling molecule that is released during wounding, thereby delaying regenerative responses in the skin. Here, we show that dissolving glycyrrhizin, a potent HMGB1 inhibitor, in water results in the formation of a hydrogel with remarkable rheological properties. We demonstrate that these glycyrrhizin-based hydrogels accelerate cutaneous wound closure in normoglycemic and diabetic mice by influencing keratinocyte migration. To facilitate topical application of glycyrrhizin hydrogels on cutaneous wounds, several concentrations of glycyrrhizinic acid in water were tested for their rheological, structural, and biological properties. By varying the concentration of glycyrrhizin, these hydrogel properties can be readily tuned, enabling customized wound care.https://www.mdpi.com/1999-4923/15/1/27wound healingglycyrrhizinhydrogelrheologyphysical hydrogel |
| spellingShingle | Maarten A. Mees Fleur Boone Thomas Bouwen Frederik Vanaerschot Charlotte Titeca Hanna-Kaisa Vikkula Leen Catrysse Anja Vananroye Erin Koos Stelios Alexandris Sabine Rosenfeldt Samuel Eyley Joachim Koetz Geert van Loo Wim Thielemans Esther Hoste Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin Pharmaceutics wound healing glycyrrhizin hydrogel rheology physical hydrogel |
| title | Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin |
| title_full | Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin |
| title_fullStr | Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin |
| title_full_unstemmed | Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin |
| title_short | Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin |
| title_sort | glycyrrhizin based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin |
| topic | wound healing glycyrrhizin hydrogel rheology physical hydrogel |
| url | https://www.mdpi.com/1999-4923/15/1/27 |
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