Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer
A Visvikis,1 SM Kyvelou,2 P Pietri,2 C Georgakopoulos,2 K Manousou,1 D Tousoulis,2 C Stefanadis,2 C Vlachopoulos,2 D Pektasides3 1Third Department of Medical Oncology, Agioi Anargyroi General Oncology Hospital of Kifissia, Athens, Greece; 2Cardiology Department, First Cardiology Clinic, Athens Medic...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-02-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cardiotoxic-profile-and-arterial-stiffness-of-adjuvant-chemotherapy-fo-peer-reviewed-article-CMAR |
| _version_ | 1818904869236375552 |
|---|---|
| author | Visvikis A Kyvelou SM Pietri P Georgakopoulos C Manousou K Tousoulis D Stefanadis C Vlachopoulos C Pektasides D |
| author_facet | Visvikis A Kyvelou SM Pietri P Georgakopoulos C Manousou K Tousoulis D Stefanadis C Vlachopoulos C Pektasides D |
| author_sort | Visvikis A |
| collection | DOAJ |
| description | A Visvikis,1 SM Kyvelou,2 P Pietri,2 C Georgakopoulos,2 K Manousou,1 D Tousoulis,2 C Stefanadis,2 C Vlachopoulos,2 D Pektasides3 1Third Department of Medical Oncology, Agioi Anargyroi General Oncology Hospital of Kifissia, Athens, Greece; 2Cardiology Department, First Cardiology Clinic, Athens Medical School, Hippokration Hospital, Athens, Greece; 3Second Department of Internal Medicine, School of Medicine, University of Athens, Athens, GreeceCorrespondence: SM KyvelouCardiology Department, First Cardiology Clinic, Athens Medical School, Hippokration Hospital, Perikelous 97B, Kato Xalandri, Athens 15231, GreeceTel +30 697283751Email smkyvel@gmail.comBackground and Purpose: Even though new cancer therapies have improved the overall survival, in some cases they have been associated with adverse effects, including increased cardiotoxicity. The purpose of the present study was to assess the cardiovascular effects of adjuvant chemotherapy for colorectal cancer and mainly the impact on arterial stiffness indices.Material and Methods: A total of 70 patients with non-metastatic colorectal cancer who were treated either with FOLFOX (n=16) or with XELOX (n=54) adjuvant chemotherapy were included in the study. All patients were subjected to full cardiovascular evaluation at the beginning and the end of chemotherapy. Arterial stiffness was assessed by means of pulse wave velocity (PWV) and augmentation index (Aix) and full laboratory examinations were conducted prior to, and soon after, the termination of chemotherapy.Results: Patients exhibited significantly higher levels of carotid-radial PWV, carotid femoral RWV and Aix post-chemotherapy (p< 0.001); these findings remained significant when examined separately in each treatment subgroup (FOLFOX, XELOX). The observed changes were independent of treatment regimen and baseline patient characteristics. Univariate regression analyses showed that baseline PWVc-r and PWVc-f were the only factors associated with PWVc-r and PWVc-f change, while Aix change was independent of its baseline value.Conclusion: There is a clear burden in arterial stiffness indices post-adjuvant chemotherapy for colorectal cancer in both chemotherapy groups. This is a finding of important clinical significance, however more prospective studies are required in order to encode the possible mechanisms involved.Keywords: arterial stiffness, adjuvant chemotherapy, colorectal cancer |
| first_indexed | 2024-12-19T21:14:17Z |
| format | Article |
| id | doaj.art-38dc491754cf425fb097e9eee9eacc80 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T21:14:17Z |
| publishDate | 2020-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-38dc491754cf425fb097e9eee9eacc802022-12-21T20:05:23ZengDove Medical PressCancer Management and Research1179-13222020-02-01Volume 121175118551803Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal CancerVisvikis AKyvelou SMPietri PGeorgakopoulos CManousou KTousoulis DStefanadis CVlachopoulos CPektasides DA Visvikis,1 SM Kyvelou,2 P Pietri,2 C Georgakopoulos,2 K Manousou,1 D Tousoulis,2 C Stefanadis,2 C Vlachopoulos,2 D Pektasides3 1Third Department of Medical Oncology, Agioi Anargyroi General Oncology Hospital of Kifissia, Athens, Greece; 2Cardiology Department, First Cardiology Clinic, Athens Medical School, Hippokration Hospital, Athens, Greece; 3Second Department of Internal Medicine, School of Medicine, University of Athens, Athens, GreeceCorrespondence: SM KyvelouCardiology Department, First Cardiology Clinic, Athens Medical School, Hippokration Hospital, Perikelous 97B, Kato Xalandri, Athens 15231, GreeceTel +30 697283751Email smkyvel@gmail.comBackground and Purpose: Even though new cancer therapies have improved the overall survival, in some cases they have been associated with adverse effects, including increased cardiotoxicity. The purpose of the present study was to assess the cardiovascular effects of adjuvant chemotherapy for colorectal cancer and mainly the impact on arterial stiffness indices.Material and Methods: A total of 70 patients with non-metastatic colorectal cancer who were treated either with FOLFOX (n=16) or with XELOX (n=54) adjuvant chemotherapy were included in the study. All patients were subjected to full cardiovascular evaluation at the beginning and the end of chemotherapy. Arterial stiffness was assessed by means of pulse wave velocity (PWV) and augmentation index (Aix) and full laboratory examinations were conducted prior to, and soon after, the termination of chemotherapy.Results: Patients exhibited significantly higher levels of carotid-radial PWV, carotid femoral RWV and Aix post-chemotherapy (p< 0.001); these findings remained significant when examined separately in each treatment subgroup (FOLFOX, XELOX). The observed changes were independent of treatment regimen and baseline patient characteristics. Univariate regression analyses showed that baseline PWVc-r and PWVc-f were the only factors associated with PWVc-r and PWVc-f change, while Aix change was independent of its baseline value.Conclusion: There is a clear burden in arterial stiffness indices post-adjuvant chemotherapy for colorectal cancer in both chemotherapy groups. This is a finding of important clinical significance, however more prospective studies are required in order to encode the possible mechanisms involved.Keywords: arterial stiffness, adjuvant chemotherapy, colorectal cancerhttps://www.dovepress.com/cardiotoxic-profile-and-arterial-stiffness-of-adjuvant-chemotherapy-fo-peer-reviewed-article-CMARarterial stiffnessadjuvant chemotherapycolorectal cancer |
| spellingShingle | Visvikis A Kyvelou SM Pietri P Georgakopoulos C Manousou K Tousoulis D Stefanadis C Vlachopoulos C Pektasides D Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer Cancer Management and Research arterial stiffness adjuvant chemotherapy colorectal cancer |
| title | Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer |
| title_full | Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer |
| title_fullStr | Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer |
| title_full_unstemmed | Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer |
| title_short | Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer |
| title_sort | cardiotoxic profile and arterial stiffness of adjuvant chemotherapy for colorectal cancer |
| topic | arterial stiffness adjuvant chemotherapy colorectal cancer |
| url | https://www.dovepress.com/cardiotoxic-profile-and-arterial-stiffness-of-adjuvant-chemotherapy-fo-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT visvikisa cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT kyvelousm cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT pietrip cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT georgakopoulosc cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT manousouk cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT tousoulisd cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT stefanadisc cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT vlachopoulosc cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer AT pektasidesd cardiotoxicprofileandarterialstiffnessofadjuvantchemotherapyforcolorectalcancer |