C-Reactive Protein and D-dimer as Prognostic Markers for Clinical Outcomes in Patients with Mild Traumatic Brain Injury: A Cross-Sectional Study
Objective: To investigate the use of prognostic markers such as C-reactive protein (CRP) and D-dimer forclinical outcomes in patients with mild traumatic brain injury (TBI).Methods: This cross-sectional study was conducted on patients with mild head trauma who were admittedto the Emergency Departmen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2023-07-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | https://beat.sums.ac.ir/article_49344_0a43a693b8117d4a0a595f3606f2504e.pdf |
| Summary: | Objective: To investigate the use of prognostic markers such as C-reactive protein (CRP) and D-dimer forclinical outcomes in patients with mild traumatic brain injury (TBI).Methods: This cross-sectional study was conducted on patients with mild head trauma who were admittedto the Emergency Department of Imam Khomeini Hospital (Sari, Iran). Data were collected from 2018 to2019. Age, sex, the time of injury hospitalization, length of hospitalization, length of unconsciousness, bloodpressure, heart rate, respiratory rate, and concomitant symptoms were all recorded using a pre-designedchecklist. The patient’s Glasgow Coma Scale (GCS), CRP, and D-dimer were also measured. Moreover, allpatients underwent CT scan.Results: This study included 74 patients with TBI. The mean age of the participants was 36.92±3.54. Themean CRP and D-dimer values were 5.69±0.77 and 0.58±0.11 in these patients, respectively. At the cut-offpoint of 11.50 for CRP, the sensitivity and specificity to detect the pathological lesions in CT scan was 75%and 95.50%, respectively (p<0.001). Additionally, with a D-dimer cut-off point of 0.90, the sensitivity andspecificity for diagnosing pathological lesions in CT scan were 100% and 98.50%, respectively (p<0.001).Conclusion: In general, the CRP and D-dimer levels of patients with mild TBI (GCS≥13) can be assessed toprotect against CT-induced radiation exposure and subsequent disorders; if they do not exhibit clinical signs toincrease the risk of adverse brain damage, such as reduced level of consciousness, drowsiness, and prolongedperiods of unconsciousness. |
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| ISSN: | 2322-2522 2322-3960 |