Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions
Objective This study aimed to determine the association of asymptomatic sexually transmitted infections (STIs), including Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Mycoplasma genitalium , Chlamydia trachomatis , and herpes simplex virus type 2, with high-risk human papillomavirus (hrHPV)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060519865633 |
| _version_ | 1819140985344491520 |
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| author | Lei Wang Lizhe Zhu Han Li Nan Ma Huifang Huang Xiaoling Zhang Ying Li Jing Fang |
| author_facet | Lei Wang Lizhe Zhu Han Li Nan Ma Huifang Huang Xiaoling Zhang Ying Li Jing Fang |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Objective This study aimed to determine the association of asymptomatic sexually transmitted infections (STIs), including Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Mycoplasma genitalium , Chlamydia trachomatis , and herpes simplex virus type 2, with high-risk human papillomavirus (hrHPV) in cervical intraepithelial lesions and neoplasms. Methods A total of 320 hrHPV-positive and 160 hrHPV-negative women were divided into high-grade squamous intraepithelial lesion (HSIL) + invasive cervical cancer and low-grade squamous intraepithelial lesion + normal subgroups, respectively, on the basis of pathological cervical lesions. Cervical brush specimens were amplified and hybridized using polymerase chain reaction kits. Results MH was associated with hrHPV infection, but not with specific hrHPV genotypes or with single or multiple genotypes. Coinfection of hrHPV and UU serotype 14 (Uup14) showed an increased risk of HSILs and cervical carcinoma (odds ratio [OR]: 12.541, 95% confidence interval [CI]: 3.625–43.390). U. urealyticum biovar (Uuu) and Uup1 infections showed a similar increased risk (OR: 11.646, 95% CI: 1.493–90.850; OR: 7.474, 95% CI: 1.140–49.015, respectively) without hrHPV. Conclusions Asymptomatic STIs are widespread. This study shows an association between UU subtypes and cervical cancer, providing new insight into cervical lesion etiology. Screening for MH, Uup14, Uup1, and Uuu is important under different hrHPV statuses. |
| first_indexed | 2024-12-22T11:47:15Z |
| format | Article |
| id | doaj.art-38dd67900ec14350ad4f8a4698895981 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-22T11:47:15Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-38dd67900ec14350ad4f8a46988959812022-12-21T18:27:07ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-11-014710.1177/0300060519865633Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesionsLei WangLizhe ZhuHan LiNan MaHuifang HuangXiaoling ZhangYing LiJing FangObjective This study aimed to determine the association of asymptomatic sexually transmitted infections (STIs), including Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Mycoplasma genitalium , Chlamydia trachomatis , and herpes simplex virus type 2, with high-risk human papillomavirus (hrHPV) in cervical intraepithelial lesions and neoplasms. Methods A total of 320 hrHPV-positive and 160 hrHPV-negative women were divided into high-grade squamous intraepithelial lesion (HSIL) + invasive cervical cancer and low-grade squamous intraepithelial lesion + normal subgroups, respectively, on the basis of pathological cervical lesions. Cervical brush specimens were amplified and hybridized using polymerase chain reaction kits. Results MH was associated with hrHPV infection, but not with specific hrHPV genotypes or with single or multiple genotypes. Coinfection of hrHPV and UU serotype 14 (Uup14) showed an increased risk of HSILs and cervical carcinoma (odds ratio [OR]: 12.541, 95% confidence interval [CI]: 3.625–43.390). U. urealyticum biovar (Uuu) and Uup1 infections showed a similar increased risk (OR: 11.646, 95% CI: 1.493–90.850; OR: 7.474, 95% CI: 1.140–49.015, respectively) without hrHPV. Conclusions Asymptomatic STIs are widespread. This study shows an association between UU subtypes and cervical cancer, providing new insight into cervical lesion etiology. Screening for MH, Uup14, Uup1, and Uuu is important under different hrHPV statuses.https://doi.org/10.1177/0300060519865633 |
| spellingShingle | Lei Wang Lizhe Zhu Han Li Nan Ma Huifang Huang Xiaoling Zhang Ying Li Jing Fang Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions Journal of International Medical Research |
| title | Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions |
| title_full | Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions |
| title_fullStr | Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions |
| title_full_unstemmed | Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions |
| title_short | Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions |
| title_sort | association between asymptomatic sexually transmitted infections and high risk human papillomavirus in cervical lesions |
| url | https://doi.org/10.1177/0300060519865633 |
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